3-氨基-4-甲基苯甲酸乙酯合成路线 （共 12 条）
反应条件
tin(ll) chloride in ethanol T=70°C; 0.5 h;
参考文献
Gilbert, Adam M.; Katz, Thomas J.; Geiger, William E.; Robben, Matthew P.; Rheingold, Arnold L.
Journal of the American Chemical Society, 1993 , vol. 115, # 8 p. 3199 - 3211
反应条件
1: 86 percent / conc. HCl / benzene / 48 h / Heating 2: 100 percent / SnCl2*2H2O / ethanol / 0.5 h / 70 °C View Scheme
参考文献
Gilbert, Adam M.; Katz, Thomas J.; Geiger, William E.; Robben, Matthew P.; Rheingold, Arnold L.
Journal of the American Chemical Society, 1993 , vol. 115, # 8 p. 3199 - 3211
反应条件
thionyl chloride Heating;
参考文献
Pan, Xiaoyan; Dong, Jinyun; Gao, Hongping; Wang, Fang; Zhang, Yanmin; Wang, Sicen; Zhang, Jie
Chemical Biology and Drug Design, 2014 , vol. 83, # 5 p. 592 - 599
反应条件
(i) H2SO4, (ii) H2, Raney-Ni, EtOH; Multistep reaction;
参考文献
Makriyannis,A. et al.
Journal of Medicinal Chemistry, 1973 , vol. 16, p. 118 - 122
反应条件
hydrogen bromide; copper(I) bromide; sodium nitrite 1.) -5 deg C, 5 min, 2.) 70 deg C, 1 h; Yield given. Multistep reaction;
参考文献
Gilbert, Adam M.; Katz, Thomas J.; Geiger, William E.; Robben, Matthew P.; Rheingold, Arnold L.
Journal of the American Chemical Society, 1993 , vol. 115, # 8 p. 3199 - 3211
反应条件
1.1: KOAc; Ac2O; isopentyl nitrite / toluene / Heating 1.2: 64 percent / HCl / 50 - 60 °C 2.1: 93 percent / LiAlH4 / tetrahydrofuran / 2 h / 0 °C View Scheme
参考文献
European Journal of Inorganic Chemistry, , # 5 p. 980 - 987
反应条件
1: With hydrogenchloride in ethanol T=90°C; 15.25 h; 2: With ammonium nitrate in water T=5 - 10°C; 1 h;
参考文献
NOVARTIS AG; NOVARTIS PHARMA GMBH
Patent: WO2004/5281 A1, 2004 ;
Location in patent: Page 37 ;
WO 2004/005281 A1
反应条件
1: hydrogenchloride / ethanol; water / 15 h / |Reflux 2: ammonium nitrate / 0.5 h / 0 °C View Scheme
参考文献
Pan, Xiaoyan; Dong, Jinyun; Gao, Hongping; Wang, Fang; Zhang, Yanmin; Wang, Sicen; Zhang, Jie
Chemical Biology and Drug Design, 2014 , vol. 83, # 5 p. 592 - 599
反应条件
1: With potassium acetate; acetic anhydride; isopentyl nitrite in toluene Heating; 2: With hydrogenchloride T=50 - 60°C;
参考文献
Carella, Alexandre; Vives, Guillaume; Cox, Tara; Jaud, Joel; Rapenne, Gwenael; Launay, Jean-Pierre
European Journal of Inorganic Chemistry, 2006 , # 5 p. 980 - 987
反应条件
1: hydrogenchloride / ethanol; water / 15 h / |Reflux 2: ammonium nitrate / 0.5 h / 0 °C 3: sodium hydroxide / butan-1-ol / 72 h / |Reflux; |Inert atmosphere 4: sodium hydroxide / ethanol; water / 4 h / 45 - 50 °C View Scheme
参考文献
Pan, Xiaoyan; Dong, Jinyun; Gao, Hongping; Wang, Fang; Zhang, Yanmin; Wang, Sicen; Zhang, Jie
Chemical Biology and Drug Design, 2014 , vol. 83, # 5 p. 592 - 599
