1-(2,3-二氯苯基)哌嗪合成路线 （共 13 条）
反应条件
1.1: 77 percent / sodium bicarbonate / acetonitrile / 5 h / 80 °C
2.1: 76 percent / hydrazine / ethanol / 2.5 h / Heating
3.1: 1,1-carbonyldiimidazole; pyridine / 1 h / 20 °C
3.2: 62 percent / CHCl3
View Scheme
参考文献
Grundt, Peter; Carlson, Erin E.; Cao, Jianjing; Bennett, Christina J.; McElveen, Elizabeth; Taylor, Michelle; Luedtke, Robert R.; Newman, Amy Hauck
Journal of Medicinal Chemistry, 2005 , vol. 48, # 3 p. 839 - 848
反应条件
potassium carbonate in acetone
Reflux;
参考文献
Newman, Amy Hauck; Beuming, Thijs; Banala, Ashwini K.; Donthamsetti, Prashant; Pongetti, Katherine; Labounty, Alex; Levy, Benjamin; Cao, Jianjing; Michino, Mayako; Luedtke, Robert R.; Javitch, Jonathan A.; Shi, Lei
Journal of Medicinal Chemistry, 2012 , vol. 55, # 15 p. 6689 - 6699
反应条件
triethylamine in dichloromethane
48 h;
参考文献
Chu, Wenhua; Tu, Zhude; McElveen, Elizabeth; Xu, Jinbin; Taylor, Michelle; Luedtke, Robert R.; MacH, Robert H.
Bioorganic and Medicinal Chemistry, 2005 , vol. 13, # 1 p. 77 - 87
