1.1: lithium diisopropyl amide / tetrahydrofuran / 1 h / -45 °C 1.2: 1 h / -45 - 20 °C 2.1: sodium hydroxide; water / methanol / 6 h / 50 °C 3.1: 1,3-bis-(diphenylphosphino)propane; triethylamine; palladium diacetate / 90 °C / |Sealed tube View Scheme