反应条件
1: 2.) NaCNBH3 / 1.) MeOH, 5 min, 2.) MeOH, reflux, overnight 2: 1.) 1-hydroxybenzotriazole (HOBt), 2.) 1-cyclohexyl-3-(2-morpholinoethyl)carbodiimide metho-p-toluenesulfonate (CMC) / 1.) CH2Cl2, 0 deg C, 10 min, 2.) CH2Cl2, RT, overnight View Scheme
参考文献
Ocain, Timothy D.; Deininger, David D.; Russo, Ralph; Senko, Nancie A.; Katz, Alan; et al.
Journal of Medicinal Chemistry, 1992 , vol. 35, # 5 p. 823 - 832
