4-氨基-3,5-二溴苯甲酸合成路线 （共 23 条）
反应条件
1: 70percent sulfuric acid / 8 h / Heating
2: 1.) sodium nitrite, conc. H2SO4; 2.) sodium borofluoride / 1.) 0-5 deg C; 2.) water, 0-5 deg C, 1 h
3: 4.7 g / copper powder / 1 h / 235 - 240 °C
View Scheme
参考文献
Ozasa, Shigeru; Fujioka, Yasuhiro; Fujiwara, Michiko; Ibuki, Eiichi
Chemical and Pharmaceutical Bulletin, 1980 , vol. 28, # 11 p. 3210 - 3222
反应条件
1: 70percent sulfuric acid / 8 h / Heating
2: 1.) sodium nitrite, conc. H2SO4; 2.) sodium borofluoride / 1.) 0-5 deg C; 2.) water, 0-5 deg C, 1 h
3: 0.80 g / copper powder / 1 h / 240 - 245 °C
View Scheme
参考文献
Ozasa, Shigeru; Fujioka, Yasuhiro; Fujiwara, Michiko; Ibuki, Eiichi
Chemical and Pharmaceutical Bulletin, 1980 , vol. 28, # 11 p. 3210 - 3222
反应条件
sulfuric acid
Diazotization.Verkochen der Loesung mit Kupferbromuerloesung;
参考文献
Sudborough
Chemische Berichte, 1894 , vol. 27, p. 514
Journal of the Chemical Society, 1895 , vol. 67, p. 595
