1: 2,4-difluoro-5-iodobenzoic acid With oxalyl dichloride; N,N-dimethyl-formamide in ethyl acetate T=20°C; 2 h; 2: ethyl-3,3-dimethylaminoacrylate With triethylamine in tetrahydrofuran 3 h; Heating / reflux; Product distribution / selectivity;

1: 2-chloro-3-pyridinecarboxylic acid chloride; ethyl-3,3-dimethylaminoacrylate With triethylamine in acetonitrile 3 h; Heating / reflux; 2: 3-bromo-aniline T=40 - 50°C; Heating / reflux;

1: ethyl 2-(2-chloronicotinoyl)acetate; ethyl-3,3-dimethylaminoacrylate With triethylamine in acetonitrile 3 h; Heating / reflux; 2: 3-bromo-aniline in acetonitrile Heating / reflux;