3-氯-6-羟基-2-硝基苯甲醛合成路线 （共 6 条）
反应条件
1,3,5,7-tetra-azatricyclo[5.1.1.13,5]decane; trifluoroacetic acid
参考文献
Lambert, Christine Marie Paul; Ple, Patrick
Patent: US2004/44015 A1, 2004 ;
反应条件
T=115°C; 1.5 h; microwave irradiation;
参考文献
Ple, Patrick A.; Green, Tim P.; Hennequin, Laurent F.; Curwen, Jon; Fennell, Michael; Allen, Jack; Lambert-Van Der Brempt, Christine; Costello, Gerard
Journal of Medicinal Chemistry, 2004 , vol. 47, # 4 p. 871 - 887
反应条件
1: 77 percent / K2CO3; Bu4NBr / toluene / 20 h / Heating
2: 98 percent / KOH / ethanol; H2O / 1 h / Heating
3: 28 percent / CuO; Cu; quinoline / 0.67 h / 210 - 230 °C
4: 45 percent / hydrazine hydrate / Raney nickel / methanol / 0.5 h / Heating
View Scheme
参考文献
Ple, Patrick A.; Green, Tim P.; Hennequin, Laurent F.; Curwen, Jon; Fennell, Michael; Allen, Jack; Lambert-Van Der Brempt, Christine; Costello, Gerard
Journal of Medicinal Chemistry, 2004 , vol. 47, # 4 p. 871 - 887
反应条件
tetrabutylammomium bromide; potassium carbonate in toluene
20 h; Heating;
参考文献
Ple, Patrick A.; Green, Tim P.; Hennequin, Laurent F.; Curwen, Jon; Fennell, Michael; Allen, Jack; Lambert-Van Der Brempt, Christine; Costello, Gerard
Journal of Medicinal Chemistry, 2004 , vol. 47, # 4 p. 871 - 887
反应条件
1: 77 percent / K2CO3; Bu4NBr / toluene / 20 h / Heating
2: 98 percent / KOH / ethanol; H2O / 1 h / Heating
3: 28 percent / CuO; Cu; quinoline / 0.67 h / 210 - 230 °C
View Scheme
参考文献
Ple, Patrick A.; Green, Tim P.; Hennequin, Laurent F.; Curwen, Jon; Fennell, Michael; Allen, Jack; Lambert-Van Der Brempt, Christine; Costello, Gerard
Journal of Medicinal Chemistry, 2004 , vol. 47, # 4 p. 871 - 887
反应条件
1: 77 percent / K2CO3; Bu4NBr / toluene / 20 h / Heating
2: 98 percent / KOH / ethanol; H2O / 1 h / Heating
View Scheme
参考文献
Ple, Patrick A.; Green, Tim P.; Hennequin, Laurent F.; Curwen, Jon; Fennell, Michael; Allen, Jack; Lambert-Van Der Brempt, Christine; Costello, Gerard
Journal of Medicinal Chemistry, 2004 , vol. 47, # 4 p. 871 - 887
