甲基-(2-哌啶-1-乙基)-胺合成路线 （共 9 条）
反应条件
1: With triethylamine in tetrahydrofuran
T=20°C; 16 h;
2: With lithium aluminium tetrahydride in tetrahydrofuran
T=0°C; 16 h; Heating / reflux;
参考文献
Maillet, Magali; Saniere, Laurent; Nicolai, Eric; Potin, Dominique; Langlois, Michel
Patent: US2005/267126 A1, 2005 ;
Location in patent: Page/Page column 30 ;
反应条件
sodium iodide; methylamine in methanol
参考文献
Taiyo Pharmaceutical Industry Co., Ltd.
Patent: US4762927 A1, 1988 ;
参考文献
Yang, Donglai; Soulier, Jean-Louis; Sicsic, Sames; Mathe-Allainmat, Monique; Bremont, Beatrice; Croci, Tiziano; Cardamone, Rosanna; Aureggi, Giulio; Langlois, Michel
Journal of Medicinal Chemistry, 1997 , vol. 40, # 4 p. 608 - 621
参考文献
Astellas Pharma Inc.
Patent: WO2009/131246 A1, 2009 ;
Location in patent: Page/Page column 78-79 ;
反应条件
potassium hydroxide; potassium iodide in water
12 h; Heating;
参考文献
Grassmann, Sven; Apelt, Joachim; Ligneau, Xavier; Pertz, Heinz H.; Arrang, Jean-Michel; Ganellin, C. Robin; Schwartz, Jean-Charles; Schunack, Walter; Stark, Holger
Archiv der Pharmazie, 2004 , vol. 337, # 10 p. 533 - 545
反应条件
1: 1 h / Heating
2: LiAlH4 / tetrahydrofuran / 4 h / Heating
View Scheme
参考文献
Hayashi, Tamio; Sawamura, Masaya; Ito, Yoshihiko
Tetrahedron, 1992 , vol. 48, # 11 p. 1999 - 2012
参考文献
De Costa; Radesca; Di Paolo; Bowen
Journal of Medicinal Chemistry, 1992 , vol. 35, # 1 p. 38 - 47
反应条件
ethanol; potassium carbonate
参考文献
Wadia et al.
Journal of Scientific and Industrial Research, 1958 , vol. 17B, p. 11,20
Chem.Abstr., 1958 , p. 15547
反应条件
2-chloro-1,3-dimethylimidazolinium chloride; triethylamine in chloroform
T=20°C; 1 h;
参考文献
Jitsuoka, Makoto; Tsukahara, Daisuke; Ito, Sayaka; Tanaka, Takeshi; Takenaga, Norihiro; Tokita, Shigeru; Sato, Nagaaki
Bioorganic and Medicinal Chemistry Letters, 2008 , vol. 18, # 18 p. 5101 - 5106
