5-溴-2,4-二(苯基甲氧基)-嘧啶合成路线 （共 5 条）
反应条件
1: benzyl alcohol With sodium hydride in toluene T=0°C; 1 h; 2: 5-Bromo-2,4-dichloror-pyrimidine in toluene
参考文献
GLAXO GROUP LIMITED
Patent: WO2007/125061 A1, 2007 ;
Location in patent: Page/Page column 48 ;
WO 2007/125061 A1
反应条件
sodium hydride in toluene T=20°C; 18 h;
参考文献
Seley, Katherine L.; Salim, Samer; Zhang, Liang; O'Daniel, Peter I.
Journal of Organic Chemistry, 2005 , vol. 70, # 5 p. 1612 - 1619
反应条件
1: With n-butyllithium; tri-isopropoxy-borane in tetrahydrofuran; hexane; toluene T=20°C; 18 h; 2: With hydrogenchloride in tetrahydrofuran; hexane; toluene
参考文献
Seley, Katherine L.; Salim, Samer; Zhang, Liang; O'Daniel, Peter I.
Journal of Organic Chemistry, 2005 , vol. 70, # 5 p. 1612 - 1619
反应条件
n-butyllithium in tetrahydrofuran T=-70°C; 0.166667 h;
参考文献
Parkanyi, Cyril; Cho, Nam Sook; Yoo, Geon Seek
Journal of Organometallic Chemistry, 1988 , vol. 342, p. 1 - 8
反应条件
toluene-4-sulfonic acid
T=165°C; 0.05 h;
参考文献
Tjarks, Werner; Gabel, Detlef
Journal of Medicinal Chemistry, 1991 , vol. 34, # 1 p. 315 - 319
