6-氯-N4-苯基-4,5-嘧啶二胺合成路线 （共 6 条）
反应条件
1: acetic acid anhydride 2: ethanol View Scheme
参考文献
Greenberg et al.
Journal of Organic Chemistry, 1959 , vol. 24, p. 1314,1315
反应条件
acetic acid; sodium nitrite in water T=0 - 20°C; 2 h;
参考文献
BAYER PHARMA AKTIENGESELLSCHAFT; HEISLER, Iring; MÜLLER, Thomas; GOLZ, Stefan; TELSER, Joachim; REHWINKEL, Hartmut; SIEBENEICHER, Holger; BUCHMANN, Bernd; ZORN, Ludwig; EIS, Knut; KOPPITZ, Marcus; LINDNER, Niels; HÉROULT, Mélanie; NEUHAUS, Roland
Patent: WO2013/182612 A1, 2013 ;
Location in patent: Page/Page column 133; 134 ;
反应条件
hydrogenchloride in ethanol; water
T=80°C;
参考文献
GREEN CROSS CORPORATION
Patent: US2012/232090 A1, 2012 ;
Location in patent: Page/Page column 20 ;
反应条件
1: 89 percent / ethanesulfonic acid / 48 h / Ambient temperature
2: 60 percent / N,N-diisopropylethylamine, NH3 / propan-1-ol / 24 h / Heating
View Scheme
参考文献
Thompson, Robert D.; Secunda, Sherrie; Daly, John W.; Olsson, Ray A.
Journal of Medicinal Chemistry, 1991 , vol. 34, # 9 p. 2877 - 2882
反应条件
acetic anhydride
T=120°C; 1 h; Microwave irradiation;
参考文献
BAYER PHARMA AKTIENGESELLSCHAFT; HEISLER, Iring; MÜLLER, Thomas; GOLZ, Stefan; TELSER, Joachim; REHWINKEL, Hartmut; SIEBENEICHER, Holger; BUCHMANN, Bernd; ZORN, Ludwig; EIS, Knut; KOPPITZ, Marcus; LINDNER, Niels; HÉROULT, Mélanie; NEUHAUS, Roland
Patent: WO2013/182612 A1, 2013 ;
Location in patent: Page/Page column 138 ;
反应条件
1: acetic acid anhydride
2: ethanol
3: aqueous KOH
View Scheme
参考文献
Greenberg et al.
Journal of Organic Chemistry, 1959 , vol. 24, p. 1314,1315
