4-氨基-3-硝基苯甲酰胺合成路线 （共 8 条）
反应条件
1: With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine in tetrahydrofuran
T=20°C; 0.166667 h;
2: With anhydrous ammonium carbonate in tetrahydrofuran
T=20°C; 16 h;
参考文献
Arienti, Kristen L.; Brunmark, Anders; Axe, Frank U.; McClure, Kelly; Lee, Alice; Blevitt, Jon; Neff, Danielle K.; Huang, Liming; Crawford, Shelby; Pandit, Chennagiri R.; Karlsson, Lars; Breitenbucher, J. Guy
Journal of Medicinal Chemistry, 2005 , vol. 48, # 6 p. 1873 - 1885
反应条件
ammonia
T=180°C; im Druckrohr;
参考文献
Grohmann
Chemische Berichte, 1890 , vol. 23, p. 3446
参考文献
Goldstein; Voegeli
Helvetica Chimica Acta, 1943 , vol. 26, p. 475,480
参考文献
Rouche
Bulletin de la Classe des Sciences, Academie Royale de Belgique, 1921 , vol. <5> 7, p. 536
Chem. Zentralbl., 1922 , vol. 93, # I p. 22
参考文献
Thieme
Journal fuer Praktische Chemie (Leipzig), 1891 , vol. <2> 43, p. 464
反应条件
1: alcoholic ammonia / 130 - 140 °C
2: concentrated aqueous ammonia
View Scheme
参考文献
Thieme
Journal fuer Praktische Chemie (Leipzig), 1891 , vol. <2> 43, p. 464
参考文献
Rouche
Bulletin de la Classe des Sciences, Academie Royale de Belgique, 1921 , vol. <5> 7, p. 536
Chem. Zentralbl., 1922 , vol. 93, # I p. 22
反应条件
hydrogen; palladium on activated charcoal in ethanol; N,N-dimethyl-formamide
T=20°C; P=2585.74 Torr; 20 h;
参考文献
Arienti, Kristen L.; Brunmark, Anders; Axe, Frank U.; McClure, Kelly; Lee, Alice; Blevitt, Jon; Neff, Danielle K.; Huang, Liming; Crawford, Shelby; Pandit, Chennagiri R.; Karlsson, Lars; Breitenbucher, J. Guy
Journal of Medicinal Chemistry, 2005 , vol. 48, # 6 p. 1873 - 1885
