4-甲氨基-3-硝基苯甲酸合成路线 （共 30 条）
反应条件
1: NaOH-solution; alcohol 2: potassium permanganate; natrium carbonate View Scheme
参考文献
Noelting; Demant
Chemische Berichte, 1904 , vol. 37, p. 1029
反应条件
1: HNO3+H2SO4 / 0 °C 2: potassium permanganate; natrium carbonate View Scheme
参考文献
Noelting; Demant
Chemische Berichte, 1904 , vol. 37, p. 1029
反应条件
1: alcohol / 130 - 140 °C / im Druckrohr 2: KOH-solution View Scheme
参考文献
Thieme
Journal fuer Praktische Chemie (Leipzig), 1891 , vol. <2> 43, p. 464
参考文献
Reverdin; de Luc
Bulletin de la Societe Chimique de France, 1908 , vol. <4> 3, p. 133
Chem. Zentralbl., 1908 , vol. 79, # I p. 1053
Full Text Show Details
Reverdin; de Luc
Chemische Berichte, 1908 , vol. 41, p. 501
Chem. Zentralbl., 1908 , vol. 79, # I p. 1053
参考文献
Reverdin; de Luc
Bulletin de la Societe Chimique de France, 1908 , vol. <4> 3, p. 133
Chem. Zentralbl., 1908 , vol. 79, # I p. 1053
Full Text Show Details
Reverdin; de Luc
Chemische Berichte, 1908 , vol. 41, p. 501
Chem. Zentralbl., 1908 , vol. 79, # I p. 1053
参考文献
Reverdin; de Luc
Bulletin de la Societe Chimique de France, 1908 , vol. <4> 3, p. 133
Chem. Zentralbl., 1908 , vol. 79, # I p. 1053
反应条件
1: 4-(methylamino)-3-nitrobenzoic acid With thionyl chloride in N,N-dimethyl-formamide T=25 - 80°C; 1.25 h; 2: 3-(pyridin-2-ylamino)propionic acid ethyl ester With triethylamine in ethyl acetate; N,N-dimethyl-formamide 1 h;
参考文献
CADILA HEALTHCARE LIMITED; DWIVEDI, Shriprakash Dhar; SINGH, Ramesh Chandra; RAVAL, Jigar Mukundbhai
Patent: WO2013/111163 A2, 2013 ;
Location in patent: Page/Page column 18 ;
反应条件
1: SOCl2 / dimethylformamide / 0.5 h / Heating 2: Et3N / tetrahydrofuran / 20 °C View Scheme
参考文献
Hauel, Norbert H.; Nar, Herbert; Priepke, Henning; Ries, Uwe; Stassen, Jean-Marie; Wienen, Wolfgang
Journal of Medicinal Chemistry, 2002 , vol. 45, # 9 p. 1757 - 1766
反应条件
thionyl chloride Chlorination; Heating;
参考文献
Dumont-Hornebeck, Beatrice; Strube, Yi Ning; Vasilescu, Daniela; Jean-Claude, Bertrand Jacques
Bioorganic and Medicinal Chemistry Letters, 2000 , vol. 10, # 20 p. 2325 - 2327
反应条件
1.1: thionyl chloride / N,N-dimethyl-formamide / 0.75 h / Reflux 1.2: 20 - 60 °C 2.1: ammonium formate / palladium on activated charcoal / ethanol / 3 h / Reflux 3.1: 1,1'-carbonyldiimidazole / tetrahydrofuran / 1 h / Reflux 3.2: 10 h / Reflux 4.1: hydrogenchloride; toluene-4-sulfonic acid / ethanol / 48 h / 20 °C 4.2: 10 - 20 °C 4.3: 0.75 h / 50 °C 5.1: potassium carbonate / water; acetone / 0.5 h / 5 °C 5.2: 1 h / 50 °C 5.3: 1 h / Reflux View Scheme
参考文献
ALEMBIC PHARMACEUTICALS LIMITED; JAYARAMAN, Venkatraman; PATEL, Samir; MISTRY, Samir; TIMBADIYA, Mukesh; PARMAR, Bhupendra; TAMBOLI, Parimal
Patent: WO2013/24384 A1, 2013 ;
