1-苄基-4-哌啶酮-3-羧酸乙酯合成路线 （共 10 条）
反应条件
hydrogenchloride in water
参考文献
Jung, Myung-Ho; Joon, Hee Hong; Cho, Jung-Hyuck; Oh, Chang-Hyun
Archiv der Pharmazie, 2008 , vol. 341, # 12 p. 780 - 786
反应条件
1: H2 / Pd/C / ethanol; H2O / 20 °C / 2585.74 Torr 2: aq. NaHCO3; NaCl / CHCl3 / 60 °C View Scheme
参考文献
Ujjainwalla, Feroze; Warner, Daniel; Snedden, Christine; Grisson, Ricky D.; Walsh, Thomas F.; Wyvratt, Matthew J.; Kalyani, Rubana N.; MacNeil, Tanya; Tang, Rui; Weinberg, David H.; Van Der Ploeg, Lex; Goulet, Mark T.
Bioorganic and Medicinal Chemistry Letters, 2005 , vol. 15, # 18 p. 4023 - 4028
反应条件
1: sodium methylate / ethanol / 24 h / |Reflux 2: trichlorophosphate / 3 h / |Inert atmosphere; |Reflux View Scheme
参考文献
Sun, Hao-Peng; Jia, Jian-Min; Jiang, Fen; Xu, Xiao-Li; Liu, Fang; Guo, Xiao-Ke; Cherfaoui, Bahidja; Huang, Hao-Ze; Pan, Yang; You, Qi-Dong
European Journal of Medicinal Chemistry, 2014 , vol. 79, p. 399 - 412
反应条件
hydrogen; palladium on activated charcoal in ethanol; water T=20°C; P=2585.74 Torr;
参考文献
Ujjainwalla, Feroze; Warner, Daniel; Snedden, Christine; Grisson, Ricky D.; Walsh, Thomas F.; Wyvratt, Matthew J.; Kalyani, Rubana N.; MacNeil, Tanya; Tang, Rui; Weinberg, David H.; Van Der Ploeg, Lex; Goulet, Mark T.
Bioorganic and Medicinal Chemistry Letters, 2005 , vol. 15, # 18 p. 4023 - 4028
反应条件
ethanol; sodium ethanolate Reflux;
参考文献
WO2013/54185 A1, ;
Page/Page column 44 ;
反应条件
sodium ethanolate in ethanol Reflux;
参考文献
Journal of Medicinal Chemistry, , vol. 51, # 11 p. 3124 - 3132
反应条件
sodium methylate in ethanol 24 h; Reflux;
参考文献
Sun, Hao-Peng; Jia, Jian-Min; Jiang, Fen; Xu, Xiao-Li; Liu, Fang; Guo, Xiao-Ke; Cherfaoui, Bahidja; Huang, Hao-Ze; Pan, Yang; You, Qi-Dong
European Journal of Medicinal Chemistry, 2014 , vol. 79, p. 399 - 412
反应条件
potassium tert-butylate in tetrahydrofuran; acetonitrile
T=60°C;
参考文献
BRISTOL-MYERS SQUIBB COMPANY; ELLSWORTH, Bruce, A.; JURICA, Elizabeth, A.; SHI, Jun; EWING, William, R.; YE, Xiang-Yang; WU, Ximao; ZHU, Yeheng; SUN, Chongqing
Patent: WO2014/78609 A1, 2014 ;
Location in patent: Paragraph 00274 ;
反应条件
1: 77 percent / Na2CO3; NaBH4 / propan-2-ol / 3 h / 20 °C
2: LiAlH4 / diethyl ether / 2 h / 20 °C
View Scheme
参考文献
NOVIRA THERAPEUTICS, INC.; HARTMAN, George D.; FLORES, Osvaldo A.
Patent: WO2013/96744 A1, 2013 ;
Location in patent: Page/Page column 200 ;
反应条件
sodium tetrahydroborate; sodium carbonate in isopropyl alcohol
T=20°C; 3 h;
参考文献
Furegati, Stefan; Ganci, Walter; Gorla, Fabrizio; Ringeisen, Urs; Rueedi, Peter
Helvetica Chimica Acta, 2004 , vol. 87, # 10 p. 2629 - 2661
