4-(2,6-二甲基苯氧基)苯胺合成路线 （共 4 条）
反应条件
1: With sulfuric acid; sodium nitrite in acetic acid T=0°C; Diazotization; 0.333333 h; 2: With sulfuric acid; water; urea Hydrolysis; 0.166667 h; Heating; Further stages.;
参考文献
Journal of Medicinal Chemistry, , vol. 43, # 9 p. 1826 - 1840
反应条件
hydrogen; palladium on activated charcoal in ethyl acetate
T=20°C; Catalytic hydrogenation; P=2280.15 Torr;
参考文献
Szajnman, Sergio H.; Yan, Wen; Bailey, Brian N.; Docampo, Roberto; Elhalem, Eleonora; Rodriguez, Juan B.
Journal of Medicinal Chemistry, 2000 , vol. 43, # 9 p. 1826 - 1840
反应条件
1: 63 percent / KOH; CuCl / dimethylsulfoxide / 16 h / 20 °C
2: 94 percent / H2 / Pd/C / ethyl acetate / 20 °C / 2280.15 Torr
View Scheme
参考文献
Szajnman, Sergio H.; Yan, Wen; Bailey, Brian N.; Docampo, Roberto; Elhalem, Eleonora; Rodriguez, Juan B.
Journal of Medicinal Chemistry, 2000 , vol. 43, # 9 p. 1826 - 1840
反应条件
1: 63 percent / KOH; CuCl / dimethylsulfoxide / 16 h / 20 °C
2: 94 percent / H2 / Pd/C / ethyl acetate / 20 °C / 2280.15 Torr
View Scheme
参考文献
Szajnman, Sergio H.; Yan, Wen; Bailey, Brian N.; Docampo, Roberto; Elhalem, Eleonora; Rodriguez, Juan B.
Journal of Medicinal Chemistry, 2000 , vol. 43, # 9 p. 1826 - 1840
