3-氨基-4-碘苯甲酸甲酯合成路线 （共 7 条）
反应条件
iron; acetic acid in ethanol T=65°C;
参考文献
ELI LILLY AND COMPANY
Patent: WO2005/40157 A2, 2005 ;
Location in patent: Page/Page column 68 ;
WO 2005/040157 A2
反应条件
thionyl chloride 3 h; Heating / reflux;
参考文献
BOEHRINGER INGELHEIM INTERNATIONAL GMBH; BOEHRINGER INGELHEIM PHARMA GMBH and CO KG
Patent: WO2004/65367 A1, 2004 ;
Location in patent: Page 108 ;
WO 2004/065367 A1
反应条件
1: H2SO4 / Heating 2: SnCl2*2H2O / ethyl acetate / Heating View Scheme
参考文献
Collini, Michael D.; Ellingboe, John W.
Tetrahedron Letters, 1997 , vol. 38, # 46 p. 7963 - 7966
反应条件
1: NaNO2, KI, HCl / 0 °C 2: H2SO4 / Heating 3: SnCl2*2H2O / ethyl acetate / Heating View Scheme
参考文献
Gabriele, Bartolo; Salerno, Giuseppe; Veltri, Lucia; Costa, Mirco; Massera, Chiara
European Journal of Organic Chemistry, 2001 , # 24 p. 4607 - 4613
反应条件
1: copper(l) iodide; bis-triphenylphosphine-palladium(II) chloride; triethylamine / tetrahydrofuran / 20 °C / Inert atmosphere 2: tetrabutyl ammonium fluoride / tetrahydrofuran / 20 °C / Inert atmosphere 3: [(η5-C5H5)Ru(PPh3)2Cl] / pyridine / 1.5 h / 90 °C / Inert atmosphere View Scheme
参考文献
Varela-Fernandez, Alejandro; Varela, Jesus A.; Saa, Carlos
Synthesis (Germany), 2012 , vol. 44, # 21 art. no. SS-2012-Z0414-PSP, p. 3285 - 3295
反应条件
sodium hydroxide in methanol Yield given;
参考文献
Collini, Michael D.; Ellingboe, John W.
Tetrahedron Letters, 1997 , vol. 38, # 46 p. 7963 - 7966
反应条件
copper(l) iodide; trans-N,N'-dimethylcyclohexane-1,2-diamine; caesium carbonate in 1,4-dioxane T=100°C; Inert atmosphere;
参考文献
Huang, Wei-Sheng; Xu, Rongsong; Dodd, Rory; Shakespeare, William C.
Tetrahedron Letters, 2013 , vol. 54, # 38 p. 5214 - 5216
