3-(2,3-二氟苯基)丙酸合成路线 （共 4 条）
反应条件
1: With oxalyl dichloride; N,N-dimethyl-formamide in dichloromethane T=0 - 20°C; 2 h; 2: With AlCl3, aluminium chloride in dichloromethane T=50°C; 16 h;
参考文献
ALLERGAN, INC.
Patent: WO2003/99795 A1, 2003 ;
Location in patent: Page 114, 115 ;
WO 03/099795 A1
反应条件
AlCl3 in hexane; dichloromethane; ethyl acetate
参考文献
Heidelbaugh, Todd M.; Chow, Ken; Nguyen, Phong; Gil, Daniel; Donello, John E.
Patent: US2005/75366 A1, 2005 ;
US 20050075366 A1
反应条件
hydrogen; palladium 10 on activated carbon in ethanol
T=20°C; 5 h;
参考文献
GLAXO GROUP LIMITED
Patent: WO2003/87088 A2, 2003 ;
Location in patent: Page/Page column 42 ;
WO 03/087088 A2
反应条件
1: With formic acid; triethylamine
T=0 - 100°C; 4 h;
2: With hydrogenchloride in water
T=0 - 5°C; pH=1 - 2;
参考文献
SYNGENTA PARTICIPATIONS AG; SYNGENTA LIMITED
Patent: WO2007/20377 A2, 2007 ;
Location in patent: Page/Page column 161 ;
