4-(1,3-苯并二氧戊环-5-基)丁酸合成路线 （共 17 条）
反应条件
hydrogen; palladium on activated charcoal
参考文献
Zjawiony, Jordan; Peterson, John R.
Organic Preparations and Procedures International, 1991 , vol. 23, # 2 p. 163 - 172
反应条件
hydrogen; palladium on activated charcoal in tetrahydrofuran
T=20°C; P=760.208 Torr; 3 h;
参考文献
Vercouillie, Johnny; Abarbri, Mohamed; Parrain, Jean-Luc; Duchene, Alain; Thibonnet, Jerome
Synthetic Communications, 2004 , vol. 34, # 20 p. 3751 - 3762
反应条件
potassium hydroxide in ethanol
2 h; Ambient temperature;
参考文献
Esteban, Gemma; Lopez-Sanchez, Miguel A.; Martinez, Ma. Eugenia; Plumet, Joaquin
Tetrahedron, 1998 , vol. 54, # 1-2 p. 197 - 212
反应条件
sodium hydroxide in 1,4-dioxane; water
3 h; Ambient temperature;
参考文献
Barreiro, Eliazer J.; Costa, Paulo R. R.; Coelho, Fernando A. S.; Farias, Florence M. C. de
Journal of Chemical Research, Miniprint, 1985 , # 7 p. 2301 - 2332
反应条件
titanium tetrachloride; propyl bromide
1.) Et2O, THF, a.) RT, 3h,b.) reflux 9h; Yield given. Multistep reaction;
参考文献
Tsuda, Yoshisuke; Ohshima, Takeshi; Hosoi, Shinzo; Kaneuchi, Satomi; Kiuchi, Fumiyuki; Toda, Jun; Sano, Takehiro
Chemical and Pharmaceutical Bulletin, 1996 , vol. 44, # 3 p. 500 - 508
反应条件
1: 41 percent / NaH / tetrahydrofuran; dimethylsulfoxide / 20 h / Ambient temperature
2: 100 percent / H2 / Pd/C
View Scheme
参考文献
Beugelmans, Rene; Chastanet, Jacqueline; Ginsburg, Helene; Quintero-Cortes, Leticia; Roussi, Georges
Journal of Organic Chemistry, 1985 , vol. 50, # 24 p. 4933 - 4938
反应条件
1: 1) 9-BBN, 2) CH3ONa / 2) dichloro<1,1'-bis(diphenylphosphino)ferrocene>palladium(II) / 1) THF, room temperature, 3 h, 2) THF, reflux, 5 h
2: 94 percent / KOH / ethanol / 2 h / Ambient temperature
View Scheme
参考文献
Esteban, Gemma; Lopez-Sanchez, Miguel A.; Martinez, Ma. Eugenia; Plumet, Joaquin
Tetrahedron, 1998 , vol. 54, # 1-2 p. 197 - 212
反应条件
1: 100 percent / H2 / 10percent Pd/C / ethyl acetate / 3102.9 Torr / Ambient temperature
2: 99 percent / 6M NaOH / dioxane; H2O / 3 h / Ambient temperature
View Scheme
参考文献
Barreiro, Eliazer J.; Costa, Paulo R. R.; Coelho, Fernando A. S.; Farias, Florence M. C. de
Journal of Chemical Research, Miniprint, 1985 , # 7 p. 2301 - 2332
反应条件
1: 96 percent / tetrahydrofuran / 0.25 h / Heating
2: 100 percent / H2 / 10percent Pd/C / ethyl acetate / 3102.9 Torr / Ambient temperature
3: 99 percent / 6M NaOH / dioxane; H2O / 3 h / Ambient temperature
View Scheme
参考文献
Barreiro, Eliazer J.; Costa, Paulo R. R.; Coelho, Fernando A. S.; Farias, Florence M. C. de
Journal of Chemical Research, Miniprint, 1985 , # 7 p. 2301 - 2332
反应条件
1: pyridine / CH2Cl2 / 1 h / 10 °C
2: NaOH/H2O / 1) EtOH, H2O, reflux, 12 h; 2) NaOH, reflux, 12 h; 3) HCl 1:1
View Scheme
参考文献
Smidrkal, Jan
Collection of Czechoslovak Chemical Communications, 1984 , vol. 49, # 6 p. 1412 - 1420
