4-(1,3-苯并二氧戊环-5-基)丁酸合成路线 （共 17 条）
反应条件
ozone; palladium on activated charcoal; hydrogen
1., Me2S; 2., piperidine-AcOH;; Yield given. Multistep reaction;
参考文献
Tsuda; Hosoi; Ohshima; et al.
Chemical and Pharmaceutical Bulletin, 1985 , vol. 33, # 8 p. 3574 - 3577
反应条件
n-propylmagnesium iodide; titanium tetrachloride
1) ether, -20 deg C; Yield given. Multistep reaction;
参考文献
Sanchez, I. H.; Mendoza, M. T.; Aguilar, M. A.; Martell, A. E.; Gonzalez, M. E.; Lemini, C.
Chemistry Letters, 1980 , p. 1501 - 1502
反应条件
magnesium
1) ether; 2) -78 deg C, 5 min; 3) HCl 1:1; Multistep reaction;
参考文献
Smidrkal, Jan
Collection of Czechoslovak Chemical Communications, 1984 , vol. 49, # 6 p. 1412 - 1420
反应条件
sodium hydroxide; water
1) EtOH, H2O, reflux, 12 h; 2) NaOH, reflux, 12 h; 3) HCl 1:1; Yield given. Multistep reaction;
参考文献
Smidrkal, Jan
Collection of Czechoslovak Chemical Communications, 1984 , vol. 49, # 6 p. 1412 - 1420
反应条件
1: oxalyl chloride / benzene / 2 h / Heating
2: AlCl3 / CS2 / 3 h / Heating
3: 48 percent / NH3(liq.), t-C4H9OK, air / Irradiation
4: 96 percent / 30percent Pd/C / 4 h / 250 °C
View Scheme
参考文献
Beugelmans, Rene; Chastanet, Jacqueline; Ginsburg, Helene; Quintero-Cortes, Leticia; Roussi, Georges
Journal of Organic Chemistry, 1985 , vol. 50, # 24 p. 4933 - 4938
反应条件
polyphosphate ester
T=20°C; Cyclization; 2 h;
参考文献
Zjawiony, Jordan; Peterson, John R.
Organic Preparations and Procedures International, 1991 , vol. 23, # 2 p. 163 - 172
反应条件
T=50 - 60°C; Destillieren des Reaktionsprodukts unter 12-15 mm Druck;
参考文献
Borsche; Eberlein
Chemische Berichte, 1914 , vol. 47, p. 1469
