1: 97 percent / Br2 / CHCl3 / Ambient temperature 2: 97 percent / DBU / acetonitrile / 0.33 h / 40 - 45 °C 3: 1.) NaOH / 1.) DMPU, room temperature, 15 min, 2.) DMPU 4: 94 percent / NaH, DMPU / dimethylformamide / 2 h / 100 °C 5: 74 percent / aq. NaOH / methanol / Heating 6: 88 percent / tetrahydrofuran / 0.75 h / Ambient temperature 7: 1.) PPh3, Pd(OAc)2, aq. Na2CO3 / 1.) DME, room temperature, 1 h, 2.) DME, reflux 8: 1.) NaH / 1.) 30 min, room temperature, 2.) room temperature, 1.5 h 9: 91 percent / POCl3 / acetonitrile / 0.5 h / Heating View Scheme

1: 6,7-dihydroxy-3,4-dihydro-1(2H)-naphthalenone With cesium fluoride in N,N-dimethyl-formamide T=20°C; deprotonation; 3 h; 2: 1,1-dibromomethane in N,N-dimethyl-formamide T=100°C; Etherification; 2 h;

polyphosphate ester T=20°C; Cyclization; 2 h;

hydrogen; trifluoroacetic anhydride; palladium on activated charcoal 1.) THF; 2.) ClCH2-CH2Cl; Yield given. Multistep reaction;

boron trifluoride diethyl etherate; mercury(II) oxide in tetrahydrofuran; water

1: 1) 9-BBN, 2) CH3ONa / 2) dichloro<1,1'-bis(diphenylphosphino)ferrocene>palladium(II) / 1) THF, room temperature, 3 h, 2) THF, reflux, 5 h 2: 94 percent / KOH / ethanol / 2 h / Ambient temperature 3: 87 percent / polyphosphonate ester / CHCl3; diethyl ether / 5 h / Ambient temperature View Scheme

1: 41 percent / NaH / tetrahydrofuran; dimethylsulfoxide / 20 h / Ambient temperature 2: 100 percent / H2 / Pd/C 3: oxalyl chloride / benzene / 2 h / Heating 4: AlCl3 / CS2 / 3 h / Heating View Scheme

in acetonitrile

1: hydrogen / Pd/C / tetrahydrofuran / 3 h / 20 °C / 760.21 Torr 2: 85 percent / trifluoroacetic anhydride / 1,2-dichloro-ethane / 0 - 20 °C View Scheme

aluminium trichloride in carbon disulfide 3 h; Heating; Yield given;