3,3'-硫代二丙酸二甲酯合成路线 （共 23 条）
反应条件
sodium methylate in tetrahydrofuran; diethyl ether T=0 - 20°C; Dieckmann Condensation; Overall yield = 78 percent; Overall yield = 185.45 mg;
参考文献
Paletta, Joseph T.; Pink, Maren; Foley, Bridget; Rajca, Suchada; Rajca, Andrzej
Organic Letters, 2012 , vol. 14, # 20 p. 5322 - 5325
反应条件
1: sodium hydride / tetrahydrofuran / 20 °C / Reflux 2: ethanol; sodium ethanolate / 20 - 70 °C 3: N,N-dimethyl-aniline; trichlorophosphate / 100 °C View Scheme
参考文献
Liu, Kevin K.-C.; Bailey, Simon; Dinh, Dac M.; Lam, Hieu; Li, Chunze; Wells, Peter A.; Yin, Min-Jean; Zou, Aihua
Bioorganic and Medicinal Chemistry Letters, 2012 , vol. 22, # 15 p. 5114 - 5117
反应条件
1: 98 percent / NaOMe / tetrahydrofuran; methanol / 3 h / 20 °C 2: 78 percent / aq. H2SO4 / 1 h / Heating View Scheme
参考文献
Rule; Detty; Kaeding; Sinicropi
Journal of Organic Chemistry, 1995 , vol. 60, # 6 p. 1665 - 1673
反应条件
Novozym 435 T=80°C; P=600.048 Torr; 48 h;
参考文献
Weber, Nikolaus; Klein, Erika; Vosmann, Klaus
Journal of Agricultural and Food Chemistry, 2006 , vol. 54, # 8 p. 2957 - 2963
反应条件
dihydrogen peroxide in acetic acid; acetone
参考文献
Vasil'eva, T. P.; Mozzhukhin, A. O.; Antipin, M. Yu.; Struchkov, Yu. T.
Bull. Russ. Acad. Sci. Div. Chem. Sci. (Engl. Transl.), 1992 , vol. 41, # 8.1 p. 1766 - 1775,1368 - 1376
反应条件
methanol; sodium tetrahydroborate in diethyl ether T=20°C; Reduction; 0.25 h;
参考文献
Khanapure, Subhash P.; Saha, Goutam; Sivendran, Sashikala; Powell, William S.; Rokach, Joshua
Tetrahedron Letters, 2000 , vol. 41, # 30 p. 5653 - 5657
反应条件
1: 98 percent / NaOMe / tetrahydrofuran; methanol / 3 h / 20 °C 2: 78 percent / aq. H2SO4 / 1 h / Heating 3: Et3N / CHCl3 / 20 °C View Scheme
参考文献
Ward, Dale E.; Rasheed, M. Abdul; Gillis, H. Martin; Beye, Garrison E.; Jheengut, Vishal; Achonduh, George T.
Synthesis, 2007 , # 10 p. 1584 - 1586
反应条件
1: Na / methanol; diethyl ether; tetrahydrofuran / 0 - 20 °C 2: p-TsOH*H2O / benzene / 16 h / Heating 3: LiAlH4 / diethyl ether / 1 h / 0 °C 4: 86 percent / (COCl)2; DMSO; i-Pr2EtN / CH2Cl2 / -78 - 20 °C View Scheme
参考文献
Ward, Dale E.; Jheengut, Vishal; Beye, Garrison E.; Gillis, H. Martin; Karagiannis, Athanasios; Becerril-Jimenez, Fabiola
Synlett, 2011 , # 4 p. 508 - 512
反应条件
1: 78 percent / NaOMe / diethyl ether / 6 h / Heating 2: 79 percent / 10percent aq. H2SO4 / 3 h / Heating 3: 89 percent / peracetic acid / ethyl acetate; acetic acid View Scheme
参考文献
Fehnel; Carmack
Journal of the American Chemical Society, 1948 , vol. 70, p. 1813,1816
反应条件
1: sodium methylate; toluene
2: aqueous sulfuric acid; acetic acid
3: diethyl ether
4: oxalic acid / Hydrieren des Reaktionsprodukts an Platin in Aethanol
View Scheme
参考文献
Onesta; Castelfranchi
Gazzetta Chimica Italiana, 1959 , vol. 89, p. 1127,1136
