4-[双[2-(乙酰氧基)乙基]氨基]苯甲醛合成路线 （共 7 条）
反应条件
1: With trichlorophosphate Vilsmeier formylation; 2: With water; sodium acetate Vilsmeier formylation;
参考文献
Ikeda, Takahiro; Tadaki, Yui; Funajima, Ryo; Tatewaki, Yoko; Okada, Shuji
Molecular Crystals and Liquid Crystals, 2011 , vol. 539, p. 482 - 487
反应条件
4-(N,N-dimethlyamino)pyridine; dicyclohexyl-carbodiimide in tetrahydrofuran T=20°C; 24 h;
参考文献
Qi, Xin; Jun, Eun Jin; Xu, Li; Kim, Sung-Jin; Hong, Jay Sung Joong; Yoon, Yeo Joon; Yoon, Juyoung
Journal of Organic Chemistry, 2006 , vol. 71, # 7 p. 2881 - 2884
反应条件
triethylamine in dichloromethane T=20°C; 6 h;
参考文献
Chiang, Chih-Chia; Mouscadet, Jean-Francois; Tsai, Hou-Jen; Liu, Chi-Tsan; Hsu, Ling-Yih
Chemical and Pharmaceutical Bulletin, 2007 , vol. 55, # 12 p. 1740 - 1743
反应条件
1.1: 93 percent / pyridine / 2 h / Heating 2.1: POCl3 / 2 h / 0 °C 2.2: 82 percent / 3 h / 90 °C View Scheme
参考文献
Moon; Shim; Lee
Molecular Crystals and Liquid Crystals Science and Technology Section A: Molecular Crystals and Liquid Crystals, 1994 , vol. 247, p. 91 - 97
反应条件
1: 87 percent / 96percent NaOH / 72 h / 100 °C 2: 83 percent / pyridine / CH2Cl2 / 24 h / Heating 3: 1.) POCl3 / 1.) ice bath cooling, 30 min, 2.) 90 deg C, 2 h View Scheme
参考文献
Moon; Shim; Lee
Molecular Crystals and Liquid Crystals Science and Technology Section A: Molecular Crystals and Liquid Crystals, 1994 , vol. 247, p. 91 - 97
反应条件
sodium carbonate in methanol; water 15 h; Ambient temperature;
参考文献
Le Bouder, Thomas; Massiot, Philippe; Le Bozec, Hubert
Tetrahedron Letters, 1998 , vol. 39, # 38 p. 6869 - 6872
反应条件
1.1: sodium carbonate / methanol / 20 °C
2.1: sodium hydride / tetrahydrofuran; mineral oil / 0.5 h / |Reflux; |Inert atmosphere
2.2: 48 h / 70 °C / |Inert atmosphere
View Scheme
参考文献
Wu, Chia-Shing; Lu, Huai-An; Chen, Chiao-Pei; Guo, Tzung-Fang; Chen, Yun
Organic and Biomolecular Chemistry, 2014 , vol. 12, # 9 p. 1430 - 1439
