叔丁氧羰基-异亮氨酰-脯氨酸合成路线 （共 5 条）
反应条件
sodium hydrogencarbonate in ethanol; acetone
T=20°C; 16 h;
参考文献
Radau, Gregor; Schermuly, Sonja; Fritsche, Alexandra
Archiv der Pharmazie, 2003 , vol. 336, # 6-7 p. 300 - 309
反应条件
sodium hydroxide in methanol
T=20°C; 2 h;
参考文献
Kumara; Channe Gowda; Rangappa
International Journal of Chemical Kinetics, 2002 , vol. 34, # 7 p. 438 - 444
反应条件
sodium hydroxide in methanol
1 h;
参考文献
Sharan, R.; Kundu, B.; Mathur, K. B.
Indian Journal of Chemistry, Section B: Organic Chemistry Including Medicinal Chemistry, 1991 , vol. 30, # 8 p. 728 - 731
反应条件
1: 83 percent / 1,3-dicyclohexylcarbodiimide / 1,2-dimethoxy-ethane / 24 h / 5 °C
2: triethylamine / dimethylformamide / 18 h / Ambient temperature
View Scheme
参考文献
Hoekstra, William J.; Sunder, Shyam S.; Cregge, Robert J.; Ashton, Louis A.; Stewart, Kenneth T.; King, Chi-Hsin R.
Tetrahedron, 1992 , vol. 48, # 2 p. 307 - 318
反应条件
1.1: 1-hydroxybenzotriazole; 1-ethyl-3-(3-dimethylaminopropyl)carbodiimide / dimethylformamide / -15 °C
1.2: 88.2 percent / N-methylmorpholine / dimethylformamide / 20 °C
2.1: 87.7 percent / aq. NaOH / methanol / 2 h / 20 °C
View Scheme
参考文献
Kumara; Channe Gowda; Rangappa
International Journal of Chemical Kinetics, 2002 , vol. 34, # 7 p. 438 - 444
