6-溴-2-四氢萘酮合成路线

参考文献

MILLENNIUM PHARMACEUTICALS, INC.; BLACKBURN, Christopher; CIAVARRI, Jeffrey; GIGSTAD, Kenneth; XU, He
Patent: WO2010/151318 A1, 2010 ;
Location in patent: Page/Page column 143-144 ;
WO 2010/151318 A1

4133-35-16-溴-2-四氢萘酮

740842-86-87-溴-2,3,4,5-四氢-1H-苯并[d]氮杂卓

参考文献

Blackburn, Christopher; Barrett, Cynthia; Chin, Janice; Garcia, Kris; Gigstad, Kenneth; Gould, Alexandra; Gutierrez, Juan; Harrison, Sean; Hoar, Kara; Lynch, Chrissie; Rowland, R. Scott; Tsu, Chris; Ringeling, John; Xu, He
Journal of Medicinal Chemistry, 2013 , vol. 56, # 18 p. 7201 - 7211

4133-35-16-溴-2-四氢萘酮+

143-33-9氰化钠+

506-87-6碳酸铵

659736-46-66'-溴螺[咪唑烷-5,2'-四氢萘]-2,4-二酮

参考文献

MERCK and CO. INC.
Patent: WO2004/82678 A1, 2004 ;
Location in patent: Page/Page column 36 ;
WO 2004/082678 A1

4133-35-16-溴-2-四氢萘酮+

143-33-9氰化钠

659736-46-66'-溴螺[咪唑烷-5,2'-四氢萘]-2,4-二酮

参考文献

MERCK and CO., INC.
Patent: WO2007/61694 A2, 2007 ;
Location in patent: Page/Page column 49; 69 ;
WO 2007/061694 A2

659736-46-66'-溴螺[咪唑烷-5,2'-四氢萘]-2,4-二酮

参考文献

MERCK and CO., INC.
Patent: WO2007/61676 A2, 2007 ;
Location in patent: Page/Page column 58 ;
WO 2007/061676 A2

773837-37-9+

4133-35-16-溴-2-四氢萘酮+

506-87-6碳酸铵

659736-46-66'-溴螺[咪唑烷-5,2'-四氢萘]-2,4-二酮

参考文献

MERCK and CO., INC.
Patent: WO2004/87649 A2, 2004 ;
Location in patent: Page 30; 34 ;
WO 2004/087649 A2

4133-35-16-溴-2-四氢萘酮+

151-50-8氰化钾

659736-46-66'-溴螺[咪唑烷-5,2'-四氢萘]-2,4-二酮

参考文献

Oishi, Shinya; Kang, Sang-Uk; Liu, Hongpeng; Zhang, Manchao; Yang, Dajun; Deschamps, Jeffrey R.; Burke Jr., Terrence R.
Tetrahedron, 2004 , vol. 60, # 13 p. 2971 - 2977

4133-35-16-溴-2-四氢萘酮+

151-50-8氰化钾+

506-87-6碳酸铵

659736-46-66'-溴螺[咪唑烷-5,2'-四氢萘]-2,4-二酮

参考文献

Cheung, Adrian Wai-Hing; Danho, Waleed; Swistok, Joseph; Qi, Lida; Kurylko, Grazyna; Rowan, Karen; Yeon, Mitch; Franco, Lucia; Chu, Xin-Jie; Chen, Li; Yagaloff, Keith
Bioorganic and Medicinal Chemistry Letters, 2003 , vol. 13, # 1 p. 133 - 137

4133-35-16-溴-2-四氢萘酮

659736-91-12-氨基-6-溴-1,2,3,4-四氢-2-萘甲酸

参考文献

Cheung, Adrian Wai-Hing; Danho, Waleed; Swistok, Joseph; Qi, Lida; Kurylko, Grazyna; Rowan, Karen; Yeon, Mitch; Franco, Lucia; Chu, Xin-Jie; Chen, Li; Yagaloff, Keith
Bioorganic and Medicinal Chemistry Letters, 2003 , vol. 13, # 1 p. 133 - 137