5,6-二甲氧基-3,3-二甲基-2,3-二氢-1H-茚-1-酮合成路线 （共 12 条）
反应条件
Celite; pyridinium chlorochromate in benzene
T=85°C; 1 h;
参考文献
Kowa Co., Ltd.
Patent: US6340682 B1, 2002 ;
Location in patent: Page column 43-44 ;
反应条件
PPA
T=60°C; Friedel-Crafts acylation; 15 h;
参考文献
Kraft, Philip; Eichenberger, Walter
European Journal of Organic Chemistry, 2003 , # 19 p. 3735 - 3743
反应条件
potassium carbonate in acetone
5 h; Heating;
参考文献
Anastasis, Panayiotis; Brown, Philip E.
Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999), 1982 , # 9 p. 2013 - 2018
参考文献
Ramana, M. M. V.; Kudav, N. A.
Indian Journal of Chemistry, Section B: Organic Chemistry Including Medicinal Chemistry, 1988 , vol. 27, # 1-12 p. 339 - 341
反应条件
methanesulfonic acid
T=70°C; 3 h;
参考文献
Camps, F.; Coll, J.; Colomina, O.; Messeguer, A.
Zeitschrift fuer Naturforschung, Teil B: Anorganische Chemie, Organische Chemie, 1984 , vol. 39, # 12 p. 1801 - 1805
反应条件
1: 49 percent / tetrahydrofuran / 0 - 20 °C
2: 69 percent / Sc(OTf)3 / nitromethane / 0.33 h / 100 °C
View Scheme
参考文献
Fillion, Eric; Fishlock, Dan; Wilsily, Ashraf; Goll, Julie M.
Journal of Organic Chemistry, 2005 , vol. 70, # 4 p. 1316 - 1327
反应条件
1: 49 percent / tetrahydrofuran / 0 - 20 °C
2: 69 percent / Sc(OTf)3 / nitromethane / 0.33 h / 100 °C
View Scheme
参考文献
Fillion, Eric; Fishlock, Dan; Wilsily, Ashraf; Goll, Julie M.
Journal of Organic Chemistry, 2005 , vol. 70, # 4 p. 1316 - 1327
反应条件
1: 1 N NaOH / tetrahydrofuran / 18 h / 50 °C
2: 94 percent / N,N-dicyclohexylcarbodiimide, 4-dimethylaminopyridine / CH2Cl2 / 6 h / Ambient temperature
3: K2CO3 / 1) methanesulfonic acid, 70 deg C, 1.5 h, 2) DMF, 50 deg C, 6 h
View Scheme
参考文献
Camps; Coll; Colomina; Messeguer
Journal of Heterocyclic Chemistry, 1985 , vol. 22, # 2 p. 363 - 368
反应条件
1: 94 percent / N,N-dicyclohexylcarbodiimide, 4-dimethylaminopyridine / CH2Cl2 / 6 h / Ambient temperature
2: K2CO3 / 1) methanesulfonic acid, 70 deg C, 1.5 h, 2) DMF, 50 deg C, 6 h
View Scheme
参考文献
Camps; Coll; Colomina; Messeguer
Journal of Heterocyclic Chemistry, 1985 , vol. 22, # 2 p. 363 - 368
反应条件
1: 51 percent / polyphosphoric acid / 1.) 40 deg C, 1h, 2.) 110 deg C, 2 h
2: 85 percent / K2CO3 / acetone / 5 h / Heating
View Scheme
参考文献
Anastasis, Panayiotis; Brown, Philip E.
Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999), 1982 , # 9 p. 2013 - 2018
