2,4,6-三氯苯甲酰氯合成路线 （共 16 条）
反应条件
1: 2,4,6-trichlorobenzoyl chloride; cyclohexanecarboxylic acid With triethylamine in tetrahydrofuran
T=20°C; Yamaguchi reaction; Inert atmosphere;
2: Hydrocinnamic alcohol With 4-(N,N-dimethlyamino)pyridine in benzene
T=20°C; Yamaguchi reaction; Inert atmosphere; chemoselective reaction;
参考文献
Shiina, Isamu; Miyao, Ryo
Heterocycles, 2008 , vol. 76, # 2 p. 1313 - 1328
反应条件
1: 2,4,6-trichlorobenzoyl chloride; benzoic acid With triethylamine in tetrahydrofuran
T=20°C; Yamaguchi reaction; Inert atmosphere;
2: Hydrocinnamic alcohol With 4-(N,N-dimethlyamino)pyridine in benzene
T=20°C; Yamaguchi reaction; Inert atmosphere; chemoselective reaction;
参考文献
Shiina, Isamu; Miyao, Ryo
Heterocycles, 2008 , vol. 76, # 2 p. 1313 - 1328
参考文献
Ross; Fuson
Journal of the American Chemical Society, 1937 , vol. 59, p. 1508
反应条件
1: diethyl malonate With tetrachloromethane; magnesium in ethanol
1.5 h; Heating / reflux;
2: 2,4,6-trichlorobenzoyl chloride in diethyl ether
72 h;
3: With sulfuric acid; acetic acid in water
T=20°C; Heating / reflux;
参考文献
Agouron Pharmaceuticals, Inc.
Patent: EP1215208 A2, 2002 ;
Location in patent: Example 107 ;
EP 1215208 A2
参考文献
Baker; Tweed
Journal of the Chemical Society, 1941 , p. 796,801
反应条件
dimethyl cadmium; benzene
参考文献
Peak; Watkins
Journal of the Chemical Society, 1950 , p. 445,450
