2-羟基-4-氨基苯甲酸甲酯合成路线 （共 46 条）
反应条件
1: 94 percent / ethanol / 3.5 h / 45 °C
2: 92 percent / potassium carbonate / acetone / 24 h / Ambient temperature
3: 83 percent / LiAlH4 / tetrahydrofuran / 2 h / 0 °C
4: 100 percent / BaMnO4 / CHCl3 / 1 h / Heating
View Scheme
参考文献
MacKenzie, A. Roderick; Moody, Christopher J.; Rees, Charles W.
Tetrahedron, 1986 , vol. 42, # 12 p. 3259 - 3268
反应条件
1: acetic acid; aqueous H2O2
2: zinc-powder; acetic acid
3: acetic acid; sodium peroxy borate
4: aqueous KOH
View Scheme
参考文献
Budziarek et al.
Journal of the Chemical Society, 1955 , p. 3158,3162, 3163
反应条件
ammonia
T=110°C; im Autoklaven;
参考文献
Jacobs; Heidelberger
Journal of the American Chemical Society, 1917 , vol. 39, p. 2437
参考文献
Jensen; Rosdahl; Ingvorsen
Acta Chemica Scandinavica (1947-1973), 1948 , vol. 2, p. 220,222
反应条件
1: 58 percent / H2 / Rh/Al / acetic acid / 70 h / 58 °C / 2740.88 Torr
2: 80 percent / 1,3,5-trimethyl-benzene / 165 °C
3: 98 percent / LAH / tetrahydrofuran / Heating
4: 96 percent / PDC / CH2Cl2
View Scheme
参考文献
Gong, Leyi; Hogg, J. Heather; Collier, James; Wilhelm, Robert S.; Soderberg, Carol
Bioorganic and Medicinal Chemistry Letters, 2003 , vol. 13, # 20 p. 3597 - 3600
反应条件
1: 58 percent / H2 / Rh/Al / acetic acid / 70 h / 58 °C / 2740.88 Torr
2: 80 percent / 1,3,5-trimethyl-benzene / 165 °C
3: 98 percent / LAH / tetrahydrofuran / Heating
4: 96 percent / PDC / CH2Cl2
5: 61 percent / tetrahydrofuran / 0 °C
6: 88 percent / H2 / PtO2 / ethyl acetate
7: 99 percent / TFA
View Scheme
参考文献
Gong, Leyi; Hogg, J. Heather; Collier, James; Wilhelm, Robert S.; Soderberg, Carol
Bioorganic and Medicinal Chemistry Letters, 2003 , vol. 13, # 20 p. 3597 - 3600
