1-甲氧基-2-苯基乙炔-苯合成路线 （共 52 条）
反应条件
1.1: Cl2Ni(1,2-bis(diphenylphosphino)ethane); 1,1-dimethylethylmagnesium chloride / tetrahydrofuran; dichloromethane / 20 °C / Inert atmosphere
1.2: 20 °C / Inert atmosphere
2.1: diisopropyl-carbodiimide / dichloromethane / 24 h / 25 °C / Inert atmosphere
View Scheme
参考文献
Wardrop, Duncan J.; Komenda, John P.
Organic Letters, 2012 , vol. 14, # 6 p. 1548 - 1551
反应条件
1.1: n-butyllithium; N,N,N',N,-tetramethylethylenediamine / tetrahydrofuran; hexane / 0.05 h / -98 °C / Inert atmosphere
1.2: 2 h / -98 - -60 °C / Inert atmosphere
1.3: Inert atmosphere
2.1: Cl2Ni(1,2-bis(diphenylphosphino)ethane); 1,1-dimethylethylmagnesium chloride / tetrahydrofuran; dichloromethane / 20 °C / Inert atmosphere
2.2: 20 °C / Inert atmosphere
3.1: diisopropyl-carbodiimide / dichloromethane / 24 h / 25 °C / Inert atmosphere
View Scheme
参考文献
Wardrop, Duncan J.; Komenda, John P.
Organic Letters, 2012 , vol. 14, # 6 p. 1548 - 1551
反应条件
1.1: Jone's reagent
2.1: n-butyllithium; N,N,N',N,-tetramethylethylenediamine / tetrahydrofuran; hexane / 0.05 h / -98 °C / Inert atmosphere
2.2: 2 h / -98 - -60 °C / Inert atmosphere
2.3: Inert atmosphere
3.1: Cl2Ni(1,2-bis(diphenylphosphino)ethane); 1,1-dimethylethylmagnesium chloride / tetrahydrofuran; dichloromethane / 20 °C / Inert atmosphere
3.2: 20 °C / Inert atmosphere
4.1: diisopropyl-carbodiimide / dichloromethane / 24 h / 25 °C / Inert atmosphere
View Scheme
参考文献
Wardrop, Duncan J.; Komenda, John P.
Organic Letters, 2012 , vol. 14, # 6 p. 1548 - 1551
反应条件
1.1: magnesium / Inert atmosphere
1.2: Inert atmosphere
2.1: Jone's reagent
3.1: n-butyllithium; N,N,N',N,-tetramethylethylenediamine / tetrahydrofuran; hexane / 0.05 h / -98 °C / Inert atmosphere
3.2: 2 h / -98 - -60 °C / Inert atmosphere
3.3: Inert atmosphere
4.1: Cl2Ni(1,2-bis(diphenylphosphino)ethane); 1,1-dimethylethylmagnesium chloride / tetrahydrofuran; dichloromethane / 20 °C / Inert atmosphere
4.2: 20 °C / Inert atmosphere
5.1: diisopropyl-carbodiimide / dichloromethane / 24 h / 25 °C / Inert atmosphere
View Scheme
参考文献
Wardrop, Duncan J.; Komenda, John P.
Organic Letters, 2012 , vol. 14, # 6 p. 1548 - 1551
反应条件
bis(acetylacetonato) palladium; triphenylphosphine in tetrahydrofuran
T=40°C; 4 h;
参考文献
Dzhemilev, U. M.; Ibragimov, A. G.; Saraev, R. A.
Bulletin of the Academy of Sciences of the USSR, Division of Chemical Science (English Translation), 1986 , vol. 35, # 2 p. 397 - 401
Izvestiya Akademii Nauk SSSR, Seriya Khimicheskaya, 1986 , # 2 p. 429 - 433
反应条件
diisobutyl-aluminum chloride; vanadyl chloride diisopropoxide
Yield given. Multistep reaction;
参考文献
Ishikawa; Ogawa; Hirao
Journal of the American Chemical Society, 1998 , vol. 120, # 20 p. 5124 - 5125
反应条件
1: PPh3 / CH2Cl2 / 1 h / 25 °C
2: 70 percent / Pd2(dba)3; TFP; DIPEA / dimethylformamide / 10 h / 80 °C
View Scheme
参考文献
Shen, Wang; Wang, Le
Journal of Organic Chemistry, 1999 , vol. 64, # 24 p. 8873 - 8879
反应条件
water; potassium carbonate in 1-methyl-pyrrolidin-2-one
T=135°C; Sonogashira Cross-Coupling; 24 h; Catalytic behavior;
参考文献
Leyva-Perez, Antonio; Oliver-Meseguer, Judit; Rubio-Marques, Paula; Corma, Avelino
Angewandte Chemie - International Edition, 2013 , vol. 52, # 44 p. 11554 - 11559
Angew. Chem., 2013 , vol. 125, # 44 p. 11768 - 11773,6
反应条件
T=700°C; flash vacuum pyrolysis;
参考文献
Aitken, R. Alan; Burns, Graham
Tetrahedron Letters, 1987 , vol. 28, # 32 p. 3717 - 3718
反应条件
2: 700 °C / flash vacuum pyrolysis
View Scheme
参考文献
Aitken, R. Alan; Burns, Graham
Tetrahedron Letters, 1987 , vol. 28, # 32 p. 3717 - 3718
