2-溴-5-氟吡啶合成路线

参考文献

SHIONOGI and CO., LTD.; EURO-CELTIQUE S.A
Patent: WO2008/8398 A2, 2008 ;
Location in patent: Page/Page column 354 ;

41404-58-42-溴-5-氟吡啶+

96649-78-4硼酸环乙醇频哪醇酯

791819-04-05-氟-2-吡啶硼酸频哪醇酯

参考文献

Clariant GmbH
Patent: EP1479685 A1, 2004 ;
Location in patent: Page/Page column 9 ;

41404-58-42-溴-5-氟吡啶+

68-12-2N,N-二甲基甲酰胺

31181-88-15-氟吡啶-2-甲醛

参考文献

Eisai RandD Management Co., Ltd.
Patent: US2007/105904 A1, 2007 ;
Location in patent: Page/Page column 87 ;

41404-58-42-溴-5-氟吡啶+

68-12-2N,N-二甲基甲酰胺

802325-29-75-氟-2-羟基甲基吡啶

参考文献

ELI LILLY AND COMPANY
Patent: WO2007/2181 A2, 2007 ;
Location in patent: Page/Page column 162-163 ;
WO 2007/002181 A2

41404-58-42-溴-5-氟吡啶+

68-12-2N,N-二甲基甲酰胺

1005291-43-92-溴-5-氟-4-甲酰基吡啶

参考文献

ASTRAZENECA UK LIMITED; ASTRAZENECA AB
Patent: WO2009/10801 A1, 2009 ;
Location in patent: Page/Page column 69-70 ;
WO 2009/010801 A1

41404-58-42-溴-5-氟吡啶+

1885-29-62-氨基苯甲腈

827579-38-4

参考文献

Su, Dai-Shi; Lim, John L.; Tinney, Elizabeth; Wan, Bang-Lin; Murphy, Kathy L.; Reiss, Duane R.; Harrell, C. Meacham; O'Malley, Stacy S.; Ransom, Rick W.; Chang, Raymond S. L.; Pettibone, Douglas J.; Yu, Jian; Tang, Cuyue; Prueksaritanont, Thomayant; Freidinger, Roger M.; Bock, Mark G.; Anthony, Neville J.
Journal of Medicinal Chemistry, 2008 , vol. 51, # 13 p. 3946 - 3952

41404-58-42-溴-5-氟吡啶

884494-34-2

参考文献

Roese, Philipp; Puenner, Florian; Hilt, Gerhard; Harms, Klaus
Synlett, 2013 , vol. 24, # 9 art. no. ST-2013-B0156-L, p. 1101 - 1104

110-85-0哌嗪+

41404-58-42-溴-5-氟吡啶

907208-90-6

参考文献

BAYER HEALTHCARE AG
Patent: WO2006/89664 A2, 2006 ;
Location in patent: Page/Page column 34 ;

41404-58-42-溴-5-氟吡啶+

97674-02-7

915720-54-61-(5-氟吡啶-2-基)乙酮

参考文献

ASTRAZENECA AB; ASTRAZENECA UK LIMITED
Patent: WO2006/123113 A2, 2006 ;
Location in patent: Page/Page column 48 ;
WO 2006/123113 A2

41404-58-42-溴-5-氟吡啶+

127-19-5N,N-二甲基乙酰胺

915720-54-61-(5-氟吡啶-2-基)乙酮

参考文献

ASTRAZENECA AB; ASTRAZENECA UK LIMITED
Patent: WO2008/117050 A1, 2008 ;
Location in patent: Page/Page column 77 ;
WO 2008/117050 A1