1: 2-bromo-5-fluoropyridine With n-butyllithium in hexanes; diethyl ether
T=-78°C; 1 h;
2: N,N-dimethyl-formamide in hexanes; diethyl ether
1 h;
3: With sodium tetrahydroborate; water; sodium hydrogencarbonate
more than 3 stages;
参考文献
ELI LILLY AND COMPANY
Patent: WO2007/2181 A2, 2007 ;
Location in patent: Page/Page column 164-165 ;
WO 2007/002181 A2
