2-(2-(苄氧基)乙基)丙二酸二乙酯合成路线 （共 13 条）
反应条件
1: alcoholic KOH-solution / Ansaeuern mit verd. Schwefelsaeure und Erhitzen des Reaktionsprodukts auf 170-180grad 2: alcoholic sulfuric acid 3: sodium; absolute alcohol; toluene View Scheme
参考文献
Bennett; Hock
Journal of the Chemical Society, 1927 , p. 481
反应条件
potassium hydroxide Ansaeuern mit verd. Schwefelsaeure und Erhitzen des Reaktionsprodukts auf 170-180grad;
参考文献
Bennett; Hock
Journal of the Chemical Society, 1927 , p. 481
反应条件
1: LiAlH4 / tetrahydrofuran / 5 h / Heating 2: pyridine / CH2Cl2 / 8 h / 20 °C 3: NaH / dimethylformamide / 3 h / 20 °C 4: H2 / 10 percent Pd/C / ethanol / 96 h View Scheme
参考文献
H. LUNDBECK A/S; ESKILDSEN, Jørgen
Patent: WO2014/49133 A1, 2014 ;
反应条件
1: diethyl malonate With sodium hydride in tetrahydrofuran
2: 1-bromo-3-oxa-4-phenyl-butane in tetrahydrofuran
T=90°C; 5 h;
参考文献
Loy, Rebecca N.; Jacobsen, Eric N.
Journal of the American Chemical Society, 2009 , vol. 131, p. 2786 - 2787
反应条件
potassium iodide in ethanol
参考文献
BEECHAM GROUP PLC
Patent: EP141927 B1, 1991 ;
反应条件
1: diethyl malonate With sodium in ethanol
0.5 h; Inert atmosphereReflux;
2: benzyl bromoethyl ether in ethanol
16 h; Reflux;
参考文献
GE HEALTHCARE LIMITED; Indrevoll, Bard; Hiscock, Duncan; Arbo, Bente Elizabeth; Bhalla, Rajiv; Glaser, Matthias Eberhard; McRobbie, Graeme Walter
Patent: US2013/189186 A1, 2013 ;
Location in patent: Paragraph 0173; 0174; 0175 ;
反应条件
1.1: pyridine / CH2Cl2 / 3 h / 20 °C
2.1: NaI / acetone / 5 h / Heating
3.1: NaH / tetrahydrofuran / 0.5 h / 20 °C
3.2: tetrahydrofuran / 5 h / Heating
View Scheme
参考文献
Fuji, Kaoru; Watanabe, Yukari; Ohtsubo, Tadamune; Nuruzzaman, Mohammad; Hamajima, Yoshio; Kohno, Michiaki
Chemical and Pharmaceutical Bulletin, 1999 , vol. 47, # 9 p. 1334 - 1337
参考文献
Kirner; Richter
Journal of the American Chemical Society, 1929 , vol. 51, p. 2505
Full Text Show Details
Bennett; Hock
Journal of the Chemical Society, 1927 , p. 481
反应条件
1: diethyl malonate With sodium hydride in tetrahydrofuran
T=20°C; Metallation; 0.5 h;
2: 1[(2-iodoethoxy)methyl]benzene in tetrahydrofuran
Condensation; 5 h; Heating;
参考文献
Fuji, Kaoru; Watanabe, Yukari; Ohtsubo, Tadamune; Nuruzzaman, Mohammad; Hamajima, Yoshio; Kohno, Michiaki
Chemical and Pharmaceutical Bulletin, 1999 , vol. 47, # 9 p. 1334 - 1337
反应条件
1.1: NaI / acetone / 5 h / Heating
2.1: NaH / tetrahydrofuran / 0.5 h / 20 °C
2.2: tetrahydrofuran / 5 h / Heating
View Scheme
参考文献
Fuji, Kaoru; Watanabe, Yukari; Ohtsubo, Tadamune; Nuruzzaman, Mohammad; Hamajima, Yoshio; Kohno, Michiaki
Chemical and Pharmaceutical Bulletin, 1999 , vol. 47, # 9 p. 1334 - 1337
