反应条件
<b>Multi-step reaction with 2 steps<br /> </b>1.1: iodine; magnesium / tetrahydrofuran / 35 - 70 °C / Inert atmosphere; Reflux; Large scale reaction<br />1.2: -20 - 30 °C / Inert atmosphere; Large scale reaction<br />2.1: Wilkinson's catalyst; hydrogen / isopropyl alcohol / 5 h / 50 - 60 °C / 3750.38 Torr / Inert atmosphere; Large scale reaction<br /> <br />
参考文献
Di Fabio, Romano; Alvaro, Giuseppe; Griffante, Cristiana; Pizzi, Domenica A.; Donati, Daniele; Mattioli, Mario; Cimarosti, Zadeo; Guercio, Giuseppe; Marchioro, Carla; Provera, Stefano; Zonzini, Laura; Montanari, Dino; Melotto, Sergio; Gerrard, Philip A.; Trist, David G.; Ratti, Emiliangelo; Corsi, Mauro Journal of Medicinal Chemistry, 2011 , vol. 54, # 4 p. 1071 - 1079
