4-(环丙烷羰基)哌嗪-1-羧酸叔丁酯合成路线 （共 4 条）
反应条件
trifluoroacetic acid in dichloromethane T=20°C; 2 h;
参考文献
Alvaro, Giuseppe; Di Fabio, Romano; Maragni, Paolo; Tampieri, Marsia; Tranquillini, Maria Elvira
Patent: US2004/14770 A1, 2004 ;
Location in patent: Page/Page column 11 ;
反应条件
hydrogenchloride in methanol T=0 - 20°C;
参考文献
BIOMARIN PHARMACEUTICAL INC.; WANG, Bing; CHU, Daniel
Patent: WO2011/130661 A1, 2011 ;
Location in patent: Page/Page column 102-103 ;
反应条件
potassium carbonate in dichloromethane
T=0 - 20°C;
参考文献
BIOMARIN PHARMACEUTICAL INC.; WANG, Bing; CHU, Daniel
Patent: WO2011/130661 A1, 2011 ;
Location in patent: Page/Page column 102 ;
反应条件
benzotriazol-1-yloxyl-tris-(pyrrolidino)-phosphonium hexafluorophosphate; N-ethyl-N,N-diisopropylamine in N,N-dimethyl-formamide
T=20°C;
参考文献
Giannini, Giuseppe; Battistuzzi, Gianfranco; Vesci, Loredana; Milazzo, Ferdinando M.; De Paolis, Francesca; Barbarino, Marcella; Guglielmi, Mario Berardino; Carollo, Valeria; Gallo, Grazia; Artali, Roberto; Dallavalle, Sabrina
Bioorganic and Medicinal Chemistry Letters, 2014 , vol. 24, # 2 p. 462 - 466
