4-异丁基哌嗪-1-羧酸叔丁酯合成路线 （共 4 条）
反应条件
1: 2-methyl propanoic acid With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine in dichloromethane
T=20°C; 0.666667 h;
2: piperazine-1-carboxylic acid tert-butyl ester in dichloromethane
T=0 - 20°C;
参考文献
BIOMARIN PHARMACEUTICAL INC.; WANG, Bing; CHU, Daniel
Patent: WO2011/130661 A1, 2011 ;
Location in patent: Page/Page column 98; 105-106 ;
反应条件
potassium carbonate in dichloromethane
T=20°C; 18 h;
参考文献
Alvaro, Giuseppe; Di Fabio, Romano; Maragni, Paolo; Tampieri, Marsia; Tranquillini, Maria Elvira
Patent: US2004/14770 A1, 2004 ;
Location in patent: Page/Page column 11 ;
反应条件
triethylamine in dichloromethane
T=0 - 20°C;
参考文献
SIENA BIOTECH S.P.A.; VARRONE, Maurizio; NENCINI, Arianna; QUINN, Joanna, Margaret; CARICASOLE, Andrea; BAKKER, Annette, Cornelia; GAVIRAGHI, Giovanni; SALERNO, Massimilano
Patent: WO2011/42145 A1, 2011 ;
Location in patent: Page/Page column 46-47 ;
WO 2011/042145 A1
反应条件
hydrogenchloride in methanol
T=0 - 20°C;
参考文献
BIOMARIN PHARMACEUTICAL INC.; WANG, Bing; CHU, Daniel
Patent: WO2011/130661 A1, 2011 ;
Location in patent: Page/Page column 98; 106 ;
