4-[1,2,3]噻唑-1-苯甲醛合成路线 （共 4 条）
反应条件
potassium carbonate in pyridine; hexane; ethyl acetate
参考文献
Japat Ltd.
Patent: US5703106 A1, 1997 ;
反应条件
potassium carbonate in N,N-dimethyl-formamide T=120°C; 1 h;
参考文献
Tanaka, Akira; Terasawa, Takeshi; Hagihara, Hiroyuki; Sakuma, Yuri; Ishibe, Noriko; Sawada, Masae; Takasugi, Hisashi; Tanaka, Hirokazu
Journal of Medicinal Chemistry, 1998 , vol. 41, # 13 p. 2390 - 2410
反应条件
1: benzaldehyde-4-boronic acid With copper(l) iodide; sodium azide in water; N,N-dimethyl-formamide T=80°C; 0.5 h; 2: acetylenecarboxylic acid With 1,8-diazabicyclo[5.4.0]undec-7-ene; sodium L-ascorbate in water; N,N-dimethyl-formamide T=80°C; 2.5 h;
参考文献
Yang, Qing; Jiang, Yubo; Kuang, Chunxiang
Helvetica Chimica Acta, 2012 , vol. 95, # 3 p. 448 - 454
反应条件
1: benzaldehyde-4-boronic acid With copper(l) iodide; sodium azide in water; N,N-dimethyl-formamide T=80°C; 0.5 h; 2: calcium carbide With 1,8-diazabicyclo[5.4.0]undec-7-ene; sodium L-ascorbate in water; N,N-dimethyl-formamide T=80°C; 3 h;
参考文献
Yang, Qing; Jiang, Yubo; Kuang, Chunxiang
Helvetica Chimica Acta, 2012 , vol. 95, # 3 p. 448 - 454
