1: With trichlorophosphate in acetonitrile
0.5 h; Heating / reflux;
2: With sodium tetrahydroborate; ammonia in methanol; water
T=20°C; pH=7 - 8; 0.25 h;
参考文献
Education Center of Traditional Chinese Medicine Co.; Hideo Nakajima
Patent: US2006/30586 A1, 2006 ;
Location in patent: Page/Page column 9 ;
Iturriaga-Vasquez, Patricio; Miquel, Raquel; Ivorra, M. Dolores; D'Ocon, M. Pilar; Cassels, Bruce K.
Journal of Natural Products, 2003 , vol. 66, # 7 p. 954 - 957
1: thionyl chloride / dichloromethane / 0.25 h
2: triethylamine / dichloromethane / 3 h / 20 °C
3: trichlorophosphate / toluene / 1.5 h / |Reflux
4: sodium tetrahydroborate / methanol / 18 h / 0 - 20 °C / |Inert atmosphere
View Scheme
参考文献
Santangelo Freel, Rose M.; Ogden, Kevin K.; Strong, Katie L.; Khatri, Alpa; Chepiga, Kathryn M.; Jensen, Henrik S.; Traynelis, Stephen F.; Liotta, Dennis C.
Journal of Medicinal Chemistry, 2013 , vol. 56, # 13 p. 5351 - 5381
1: triethylamine / dichloromethane / 3 h / 20 °C
2: trichlorophosphate / toluene / 1.5 h / |Reflux
3: sodium tetrahydroborate / methanol / 18 h / 0 - 20 °C / |Inert atmosphere
View Scheme
参考文献
Santangelo Freel, Rose M.; Ogden, Kevin K.; Strong, Katie L.; Khatri, Alpa; Chepiga, Kathryn M.; Jensen, Henrik S.; Traynelis, Stephen F.; Liotta, Dennis C.
Journal of Medicinal Chemistry, 2013 , vol. 56, # 13 p. 5351 - 5381
1: triethylamine / dichloromethane / 3 h / 20 °C
2: trichlorophosphate / toluene / 1.5 h / |Reflux
3: sodium tetrahydroborate / methanol / 18 h / 0 - 20 °C / |Inert atmosphere
View Scheme
参考文献
Santangelo Freel, Rose M.; Ogden, Kevin K.; Strong, Katie L.; Khatri, Alpa; Chepiga, Kathryn M.; Jensen, Henrik S.; Traynelis, Stephen F.; Liotta, Dennis C.
Journal of Medicinal Chemistry, 2013 , vol. 56, # 13 p. 5351 - 5381
