1,1,2-三甲基苯-1H-苯并[e]吲哚合成路线 （共 12 条）
反应条件
benzene und Behandeln das entstandene β-Naphtylhydrazon mit wasserfreier Oxalsaeure in alkoh.Loesung;
参考文献
Societe D'etudes et de Recherches Biologiques
Patent: US5750722 A1, 1998 ;
参考文献
Fischer,E.; Steche
Chemische Berichte, 1887 , vol. 20, p. 818,2199
Justus Liebigs Annalen der Chemie, 1887 , vol. 242, p. 353
反应条件
1: acetonitrile / |Reflux 2: sodium acetate / acetic anhydride / 50 °C View Scheme
参考文献
Mapp, Carla T.; Owens, Eric A.; Henary, Maged; Grant, Kathryn B.
Bioorganic and Medicinal Chemistry Letters, 2014 , vol. 24, # 1 p. 214 - 219
反应条件
sulfuric acid, fuming in nitrobenzene T=20°C; Cooling with ice;
参考文献
Langhals, Heinz; Varja, Ana; Laubichler, Peter; Kernt, Marcus; Eibl, Kirsten; Haritoglou, Christos
Journal of Medicinal Chemistry, 2011 , vol. 54, # 11 p. 3903 - 3925
反应条件
in acetonitrile T=110°C; 48 h; Inert atmosphere;
参考文献
Kiyose, Kazuki; Hanaoka, Kenjiro; Oushiki, Daihi; Nakamura, Tomomi; Kajimura, Mayumi; Suematsu, Makoto; Nishimatsu, Hiroaki; Yamane, Takehiro; Terai, Takuya; Hirata, Yasunobu; Nagano, Tetsuo
Journal of the American Chemical Society, 2010 , vol. 132, # 45 p. 15846 - 15848
反应条件
in 1,2-dichloro-benzene T=120°C; 24 h;
参考文献
Mizrahi, Dana M.; Ziv-Polat, Ofra; Perlstein, Benny; Gluz, Eran; Margel, Shlomo
European Journal of Medicinal Chemistry, 2011 , vol. 46, # 10 p. 5175 - 5183
参考文献
Jetty, Ragini; Bandera, Yuriy P.; Daniele, Michael A.; Hanor, David; Hung, Hsin-I.; Ramshesh, Venkat; Duperreault, Megan F.; Nieminen, Anna-Liisa; Lemasters, John J.; Foulger, Stephen H.
Journal of Materials Chemistry B, 2013 , vol. 1, # 36 p. 4542 - 4554
参考文献
Mank; Van Der Laan; Lingeman; Goojjer; Brinkman; Velthorst
Analytical Chemistry, 1995 , vol. 67, # 10 p. 1742 - 1748
参考文献
AIAMEDICS GmbH and Co. KG; Langhals, Heinz; Laubichler, Peter; Haritoglou, Christos; Varja, Ana
Patent: US2013/131354 A1, 2013 ;
Location in patent: Paragraph 0100 ;
反应条件
N-bromosuccinmide; 2,2'-azo-bisisobutyronitrile in dichloromethane
5 h; Irradiation with UV lightHeating / reflux;
参考文献
Roche Diagnostics Operations, Inc.
Patent: US2006/199223 A1, 2006 ;
