4-(4-氟苯(甲)酰)吡啶合成路线 （共 5 条）
反应条件
hydrogenchloride; sodium hydroxide in diethyl ether
参考文献
A. H. Robins Company, Incorporated
Patent: US4950674 A1, 1990 ;
反应条件
hydrogenchloride; aluminium trichloride in o-di-fluorobenzene; toluene
参考文献
Janssen Pharmaceutica N.V.
Patent: US4485107 A1, 1984 ;
反应条件
1: NaBH4 / ethanol / 0.5 h / Ambient temperature 2: phosphorous, 57percent aq. HI / acetic acid / 10 h / Heating View Scheme
参考文献
Shanklin, James R.; Johnson, Christopher P.; Proakis, Anthony G.; Barrett, Richard J.
Journal of Medicinal Chemistry, 1991 , vol. 34, # 10 p. 3011 - 3022
反应条件
sodium tetrahydroborate in ethanol 0.5 h; Ambient temperature;
参考文献
Shanklin, James R.; Johnson, Christopher P.; Proakis, Anthony G.; Barrett, Richard J.
Journal of Medicinal Chemistry, 1991 , vol. 34, # 10 p. 3011 - 3022
反应条件
palladium 10 on activated carbon; hydrogen in methanol; 1,2-dichloro-ethane
T=25°C; 12 h; chemoselective reaction;
参考文献
Cheng, Chuanjie; Wang, Bo; Liu, Nan; Chen, Wenwen; Wang, Xinyan; Hu, Yuefei
Tetrahedron, 2014 , vol. 70, # 4 p. 930 - 935
