3-烯丙基-8-苄基-3,8-二氮杂双环[3.2.1]辛烷合成路线 （共 4 条）
反应条件
N,N'-dimethyl-barbituric acid; tris(dibenzylideneacetone)dipalladium(0) chloroform complex; triphenylphosphine in dichloromethane 3 h; Heating / reflux;
参考文献
JANSSEN PHARMACEUTICA, N.V.
Patent: WO2007/81995 A2, 2007 ;
Location in patent: Page/Page column 191 ;
WO 2007/081995 A2
反应条件
sodium hydroxide; tris-(dibenzylideneacetone)dipalladium(0) in dichloromethane
参考文献
Bjorsne, Magnus; Hoffmann, Kurt-Jurgen; Ponten, Fritiof; Strandlund, Gert; Svensson, Peder; Wilstermann, Michael
Patent: US2004/23971 A1, 2004 ;
反应条件
sodium hydroxide; NaHCO3; NaI in methanol; acetonitrile
参考文献
Bjorsne, Magnus; Hoffmann, Kurt-Jurgen; Ponten, Fritiof; Strandlund, Gert; Svensson, Peder; Wilstermann, Michael
Patent: US2004/23971 A1, 2004 ;
反应条件
sodium hydrogencarbonate; sodium iodide in acetonitrile
5 h; Heating / reflux;
参考文献
JANSSEN PHARMACEUTICA, N.V.
Patent: WO2007/81995 A2, 2007 ;
Location in patent: Page/Page column 191 ;
WO 2007/081995 A2
