4-(二甲氨基)邻羟苄基合成路线 （共 16 条）
反应条件
1: N,N-dimethyl-formamide With trichlorophosphate 0.0833333 h; 2: 3-dimethylamino-phenol T=20 - 70°C; 2 h;
参考文献
Takakura, Hideo; Sasakura, Kiyoshi; Ueno, Tasuku; Urano, Yasuteru; Terai, Takuya; Hanaoka, Kenjiro; Tsuboi, Takashi; Nagano, Tetsuo
Chemistry - An Asian Journal, 2010 , vol. 5, # 9 p. 2053 - 2061
反应条件
in N,N-dimethyl-formamide T=60 - 70°C; 1 h;
参考文献
Barrio, Jorge R.; Petric, Andre J.; Satyamurthy, Nagichettiar; Kepe, Vladimir; Small, Gary W.
Patent: US2007/53831 A1, 2007 ;
Location in patent: Page/Page column 11 ;
反应条件
aluminium trichloride in chloroform 0.166667 h; Ambient temperature;
参考文献
Akiyama, Shuzo; Akimoto, Hiroyuki; Nakatsuji, Shin'ichi; Nakashima, Kenichiro
Bulletin of the Chemical Society of Japan, 1985 , vol. 58, # 8 p. 2192 - 2196
反应条件
1: 1.) sodium hydride / 1.) diethyl ether, DMF, 15 min, 2.) RT, 1.5 h 2: 1.) sec-BuLi, TMEDA / 1.) cyclohexane, THF, -78 deg C, 1 h, 2.) a) -78 deg C, 4 h, b) from -78 deg C to RT, 2 h, c) RT, 0.5 h View Scheme
参考文献
Skowronska-Ptasinska, Maria; Verboom, Willem; Reinhoudt, David N.
Journal of Organic Chemistry, 1985 , vol. 50, # 15 p. 2690 - 2698
反应条件
N,N,N',N,-tetramethylethylenediamine; sec.-butyllithium 1.) cyclohexane, THF, -78 deg C, 1 h, 2.) a) -78 deg C, 4 h, b) from -78 deg C to RT, 2 h, c) RT, 0.5 h; Yield given. Multistep reaction. Yields of byproduct given;
参考文献
Skowronska-Ptasinska, Maria; Verboom, Willem; Reinhoudt, David N.
Journal of Organic Chemistry, 1985 , vol. 50, # 15 p. 2690 - 2698
反应条件
(alkaline hydrolysis);
参考文献
Hullar,T.L.; Failla,D.L.
Journal of Medicinal Chemistry, 1969 , vol. 12, # 3 p. 420 - 424
反应条件
1: (formylation) 2: (alkaline hydrolysis) View Scheme
参考文献
Hullar,T.L.; Failla,D.L.
Journal of Medicinal Chemistry, 1969 , vol. 12, # 3 p. 420 - 424
参考文献
Geigy and Co.
Patent: DE105103 ;
反应条件
potassium carbonate in N,N-dimethyl-formamide T=50°C; 8 h;
参考文献
Kim, Byung-Soon; Kashibuchi, Daisuke; Son, Young-A.; Kim, Sung-Hoon; Matsumoto, Shinya
Dyes and Pigments, 2011 , vol. 90, # 1 p. 56 - 64
反应条件
in ethanol; N,N-dimethyl-formamide T=110°C; 2 h;
参考文献
Akiyama, Shuzo; Akimoto, Hiroyuki; Nakatsuji, Shin'ichi; Nakashima, Kenichiro
Bulletin of the Chemical Society of Japan, 1985 , vol. 58, # 8 p. 2192 - 2196
