(2-甲氧基苯甲酰)乙酸乙酯合成路线 （共 19 条）
反应条件
1: ethyl acetate With lithium diisopropyl amide in tetrahydrofuran T=-70 - -65°C; 0.5 h; 2: 2-methoxy-benzoyl chloride in tetrahydrofuran T=-70 - -65°C; 0.5 h; 3: With hydrogenchloride in tetrahydrofuran; water T=-70 - 25°C;
参考文献
SCHERING CORPORATION; PHARMACOPEIA, INC.
Patent: WO2004/22560 A1, 2004 ;
Location in patent: Page 32-33 ;
WO 2004/022560 A1
反应条件
sodium hydride in toluene; mineral oil
参考文献
Chen, Yi-Fong; Lin, Yi-Chien; Huang, Po-Kai; Chan, Hsu-Chin; Kuo, Sheng-Chu; Lee, Kuo-Hsiung; Huang, Li-Jiau
Bioorganic and Medicinal Chemistry, 2013 , vol. 21, # 17 p. 5064 - 5075
反应条件
magnesium diethoxide in tetrahydrofuran T=0 - 20°C; Heating / reflux;
参考文献
EVOLVA SA
Patent: US2011/178112 A1, 2011 ;
Location in patent: Page/Page column 20; 22; 24 ;
反应条件
aluminum oxide T=25°C; 3 h;
参考文献
Karche; Jachak; Dhavale
Journal of Organic Chemistry, 2001 , vol. 66, # 19 p. 6323 - 6332
反应条件
ammonium hydroxide; sodium hydroxide; water; ammonium chloride T=50°C; 3 h;
参考文献
Sicker, Dieter; Mann, Gerhard
Collection of Czechoslovak Chemical Communications, 1988 , vol. 53, # 4 p. 839 - 850
反应条件
sodium ethanolate T=0 - 5°C;
参考文献
Zhu, Youquan; Zou, Xiaomao; Hu, Fangzhong; Yao, Changsheng; Liu, Bin; Yang, Huazheng
Journal of Agricultural and Food Chemistry, 2005 , vol. 53, # 24 p. 9566 - 9570
反应条件
toluene-4-sulfonic acid in water 5 h; Heating; Yield given;
参考文献
Grohe, Klaus; Heitzer, Helmut
Liebigs Annalen der Chemie, 1987 , p. 29 - 37
反应条件
1: 1.) Mg/ethanol, CCl4 / 1.) ethanol, toluene, 1 h, 60-70 deg C; 2.) toluene, 0 to -5 deg C; 12 h, room temperature 2: p-toluenesulfonic acid / H2O / 5 h / Heating View Scheme
参考文献
Sicker, Dieter; Mann, Gerhard
Collection of Czechoslovak Chemical Communications, 1988 , vol. 53, # 4 p. 839 - 850
反应条件
1.1: potassium hydroxide / ethanol / 0.33 h / 20 °C / Cooling 2.1: magnesium diethoxide / tetrahydrofuran / 1.5 h / Reflux 2.2: 0 - 20 °C View Scheme
参考文献
EVOLVA SA
Patent: US2011/178112 A1, 2011 ;
反应条件
sodium; ethyl acetate
参考文献
Kindler; Peschke
Archiv der Pharmazie (Weinheim, Germany), 1933 , vol. 271, p. 431,435
