3-甲氧基-4-氨基苯甲酸甲酯合成路线 （共 25 条）
反应条件
manganese(IV) oxide; diisobutylaluminium hydride
Yield given. Multistep reaction;
参考文献
Knoelker, Hans-Joachim; Bauermeister, Michael
Tetrahedron, 1993 , vol. 49, # 48 p. 11221 - 11236
反应条件
1: With bromine in methanol; acetic acid
T=20°C; 7 h;
2: With sodium hydrogencarbonate in water
参考文献
DECODE GENETICS EHF
Patent: US2009/130076 A1, 2009 ;
Location in patent: Page/Page column 31; 32 ;
US 20090130076 A1
反应条件
1: sulfuric acid; potassium iodide; sodium nitrite / water / 1.5 h / -5 °C
2: copper(l) iodide / 100 - 110 °C / Inert atmosphere
3: lithium aluminium tetrahydride / tetrahydrofuran / 20 °C
4: oxalyl dichloride / dichloromethane; dimethyl sulfoxide / 5 h / -60 °C / Inert atmosphere
View Scheme
参考文献
Zhang, Qin; Zhong, Ying; Yan, Lin-Na; Sun, Xun; Gong, Tao; Zhang, Zhi-Rong
Bioorganic and Medicinal Chemistry Letters, 2011 , vol. 21, # 3 p. 1010 - 1014
反应条件
1: lithium aluminium tetrahydride / tetrahydrofuran / 20 °C
2: manganese(IV) oxide / tetrahydrofuran / 3 h / Reflux
View Scheme
参考文献
Zhang, Qin; Zhong, Ying; Yan, Lin-Na; Sun, Xun; Gong, Tao; Zhang, Zhi-Rong
Bioorganic and Medicinal Chemistry Letters, 2011 , vol. 21, # 3 p. 1010 - 1014
反应条件
1: dicyclohexyl(2′,6′-dimethoxybiphenyl-2-yl)phosphine; palladium diacetate; caesium carbonate / toluene / 40 h / Reflux
2: palladium diacetate; potassium carbonate; 2,2,2-trimethylacetic acid / 14 h / 115 °C
3: lithium aluminium tetrahydride / diethyl ether; dichloromethane / 4.5 h / 20 °C
View Scheme
参考文献
Thomas, Claudia; Knoelker, Hans-Joachim
Tetrahedron Letters, 2013 , vol. 54, # 6 p. 591 - 593
