1,3-二甲基-5-硝基尿嘧啶水合物合成路线 （共 28 条）
反应条件
sodium hydride in N,N-dimethyl-formamide 4 h; Cooling with iceInert atmosphere;
参考文献
NOVARTIS AG; FURET, Pascal; GUAGNANO, Vito; HOLZER, Philipp; KALLEN, Joerg; LIAO, Lv; MAH, Robert; MAO, Liang; MASUYA, Keiichi; SCHLAPBACH, Achim; STUTZ, Stefan; VAUPEL, Andrea
Patent: WO2013/111105 A1, 2013 ;
Location in patent: Page/Page column 280 ;
反应条件
sodium hydroxide; tetrabutylammomium bromide in dichloromethane T=20°C; 24 h;
参考文献
Hedayatullah, Mir
Journal of Heterocyclic Chemistry, 1981 , vol. 18, p. 339 - 342
反应条件
tetra(n-butyl)ammonium hydroxide in methanol; acetonitrile T=40°C; 72 h;
参考文献
Pecorari; Vampa; Albasini; Rinaldi; Melegari; Costi
Farmaco, Edizione Scientifica, 1988 , vol. 43, # 4 p. 311 - 318
反应条件
triethylamine in ethanol 6 h; Ambient temperatureethanol, 5 min, reflux;
参考文献
Hirota, Kosaku; Kitade, Yukio; Sajiki, Hironao; Maki, Yoshifumi; Yogo, Motoi
Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999), 1990 , # 2 p. 367 - 373
反应条件
acetic anhydride; copper(II) nitrate 48 h; Ambient temperature;
参考文献
Giziewicz, Jerzy; Wnuk, Stanislaw F.; Robins, Morris J.
Journal of Organic Chemistry, 1999 , vol. 64, # 6 p. 2149 - 2151
反应条件
in methanol 0.5 h; Ambient temperature;
参考文献
Hirota, Kosaku; Kitade, Yukio; Sajiki, Hironao; Maki, Yoshifumi; Yogo, Motoi
Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999), 1990 , # 2 p. 367 - 373
反应条件
in N,N-dimethyl-formamide T=120°C;
参考文献
Hirota, Kosaku; Kitade, Yukio; Sajiki, Hironao; Maki, Yoshifumi
Heterocycles, 1985 , vol. 23, # 1 p. 205
反应条件
1: 73 percent / nitric acid / H2SO4 / 0.5 h / 10 °C 2: 95 percent / methanol / 0.5 h / Ambient temperature View Scheme
参考文献
Hirota, Kosaku; Kitade, Yukio; Sajiki, Hironao; Maki, Yoshifumi; Yogo, Motoi
Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999), 1990 , # 2 p. 367 - 373
反应条件
in ethanol Ambient temperature;
参考文献
Hirota, Kosaku; Kitade, Yukio; Sajiki, Hironao; Maki, Yoshifumi
Tetrahedron Letters, 1986 , vol. 27, # 28 p. 3263 - 3266
反应条件
in ethanol; water 10 h; Ambient temperature;
参考文献
Hirota, Kosaku; Kitade, Yukio; Sajiki, Hironao; Maki, Yoshifumi; Yogo, Motoi
Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999), 1990 , # 2 p. 367 - 373
