2-氨基-6-氯苯甲酸甲酯合成路线 （共 21 条）
反应条件
sulfuric acid 12 h; Heating;
参考文献
Hinsberger, Stefan; Huesecken, Kristina; Groh, Matthias; Negri, Matthias; Haupenthal, Joerg; Hartmann, Rolf W.
Journal of Medicinal Chemistry, 2013 , vol. 56, # 21 p. 8332 - 8338
反应条件
sulfuric acid T=40 - 50°C;
参考文献
BASF
Patent: DE231962 ;
Fortschr. Teerfarbenfabr. Verw. Industriezweige, vol. 10, p. 168
反应条件
1: SOCl2 / 2 h / Heating 2: 20.2 g / 1 h / Heating View Scheme
参考文献
BASF
Patent: DE231962 ;
Fortschr. Teerfarbenfabr. Verw. Industriezweige, vol. 10, p. 168
反应条件
1: (i) H2SO4, (ii) aq. NaNO2 2: FeSO4 View Scheme
参考文献
Andrews,B.D. et al.
Australian Journal of Chemistry, 1972 , vol. 25, p. 639 - 646
反应条件
1: FeSO4 View Scheme
参考文献
Andrews,B.D. et al.
Australian Journal of Chemistry, 1972 , vol. 25, p. 639 - 646
反应条件
hydrogenchloride Pinner reaction;
参考文献
Hamprecht, Gerhard; Wuerzer, Bruno; Witschel, Matthias
Chimia, 2004 , vol. 58, # 3 p. 117 - 122
反应条件
Esterification; 1 h; Heating;
参考文献
Kondo, Kazumi; Ogawa, Hidenori; Yamashita, Hiroshi; Miyamoto, Hisashi; Tanaka, Michinori; Nakaya, Kenji; Kitano, Kazuyoshi; Yamamura, Yoshitaka; Nakamura, Shigeki; Onogawa, Toshiyuki; Mori, Toyoki; Tominaga, Michiaki
Bioorganic and Medicinal Chemistry, 1999 , vol. 7, # 8 p. 1743 - 1754
参考文献
Andrews,B.D. et al.
Australian Journal of Chemistry, 1972 , vol. 25, p. 639 - 646
参考文献
BASF
Patent: DE231962 ;
Fortschr. Teerfarbenfabr. Verw. Industriezweige, vol. 10, p. 168
反应条件
1.1: 92 percent / pyridine / 20 °C 2.1: 100 percent / K2CO3 / dimethylformamide / 4 h / 120 °C 3.1: t-BuOK / toluene / 0.5 h / Heating 3.2: 14 percent / conc. HCl / acetic acid / 5 h / Heating 4.1: 95 percent / polyphosphoric acid / 1.5 h / 80 - 100 °C View Scheme
参考文献
Kondo, Kazumi; Ogawa, Hidenori; Yamashita, Hiroshi; Miyamoto, Hisashi; Tanaka, Michinori; Nakaya, Kenji; Kitano, Kazuyoshi; Yamamura, Yoshitaka; Nakamura, Shigeki; Onogawa, Toshiyuki; Mori, Toyoki; Tominaga, Michiaki
Bioorganic and Medicinal Chemistry, 1999 , vol. 7, # 8 p. 1743 - 1754
