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乙二醇
甲醛
63148-62-9
MDI
丁酮
二甲基亚砜
碳酸氢钠
471-34-1
拉坦前列腺素(游离酸)
合成路线
（共 47 条）
930118-48-2
→
反应条件
41639-83-2
拉坦前列腺素(游离酸)
反应条件
1: 45 mg / PPTS / acetone; H2O / 6 h / 20 °C 2: 96 percent / LiOH*H2O / methanol; H2O / 20 h / 20 °C View Scheme
参考文献
Martynow, Jacek G.; Jozwik, Julita; Szelejewski, Wieslaw; Achmatowicz, Osman; Kutner, Andrzej; Wisniewski, Krzysztof; Winiarski, Jerzy; Zegrocka-Stendel, Oliwia; Golebiewski, Piotr
European Journal of Organic Chemistry, 2007 , # 4 p. 689 - 703
913258-28-3
→
反应条件
41639-83-2
拉坦前列腺素(游离酸)
反应条件
1: 95 percent / PPTS / acetone; H2O / 5 h / 18 °C 2: 99 percent / LiOH*H2O / methanol; H2O / 8 h View Scheme
参考文献
Martynow, Jacek G.; Jozwik, Julita; Szelejewski, Wieslaw; Achmatowicz, Osman; Kutner, Andrzej; Wisniewski, Krzysztof; Winiarski, Jerzy; Zegrocka-Stendel, Oliwia; Golebiewski, Piotr
European Journal of Organic Chemistry, 2007 , # 4 p. 689 - 703
913258-25-0
→
反应条件
41639-83-2
拉坦前列腺素(游离酸)
反应条件
1: 227 mg / Na2HPO4; Na/Hg / methanol / 2 h 2: 45 mg / PPTS / acetone; H2O / 6 h / 20 °C 3: 96 percent / LiOH*H2O / methanol; H2O / 20 h / 20 °C View Scheme
参考文献
Martynow, Jacek G.; Jozwik, Julita; Szelejewski, Wieslaw; Achmatowicz, Osman; Kutner, Andrzej; Wisniewski, Krzysztof; Winiarski, Jerzy; Zegrocka-Stendel, Oliwia; Golebiewski, Piotr
European Journal of Organic Chemistry, 2007 , # 4 p. 689 - 703
124988-64-3
→
反应条件
41639-83-2
拉坦前列腺素(游离酸)
反应条件
1: 67.4 percent / Bu2SnO; Et3N / CH2Cl2 / 0 - 20 °C 2: 99.5 percent / imidazole; Et3N / dimethylformamide / 1.33 h / 0 - 20 °C 3: 89 percent / NaI; pyridine / dimethylformamide / 2.5 h / 75 - 80 °C 4: 99 percent / LiOH*H2O / methanol; H2O / 8 h View Scheme
参考文献
Martynow, Jacek G.; Jozwik, Julita; Szelejewski, Wieslaw; Achmatowicz, Osman; Kutner, Andrzej; Wisniewski, Krzysztof; Winiarski, Jerzy; Zegrocka-Stendel, Oliwia; Golebiewski, Piotr
European Journal of Organic Chemistry, 2007 , # 4 p. 689 - 703
118629-73-5
→
反应条件
41639-83-2
拉坦前列腺素(游离酸)
反应条件
1: 99.5 percent / imidazole; Et3N / dimethylformamide / 1.33 h / 0 - 20 °C 2: 89 percent / NaI; pyridine / dimethylformamide / 2.5 h / 75 - 80 °C 3: 99 percent / LiOH*H2O / methanol; H2O / 8 h View Scheme
参考文献
Martynow, Jacek G.; Jozwik, Julita; Szelejewski, Wieslaw; Achmatowicz, Osman; Kutner, Andrzej; Wisniewski, Krzysztof; Winiarski, Jerzy; Zegrocka-Stendel, Oliwia; Golebiewski, Piotr
European Journal of Organic Chemistry, 2007 , # 4 p. 689 - 703
157732-87-1
→
反应条件
41639-83-2
拉坦前列腺素(游离酸)
反应条件
1: 99 percent / PTSA / methanol / 4 h / 40 °C 2: 67.4 percent / Bu2SnO; Et3N / CH2Cl2 / 0 - 20 °C 3: 99.5 percent / imidazole; Et3N / dimethylformamide / 1.33 h / 0 - 20 °C 4: 89 percent / NaI; pyridine / dimethylformamide / 2.5 h / 75 - 80 °C 5: 99 percent / LiOH*H2O / methanol; H2O / 8 h View Scheme
参考文献
Martynow, Jacek G.; Jozwik, Julita; Szelejewski, Wieslaw; Achmatowicz, Osman; Kutner, Andrzej; Wisniewski, Krzysztof; Winiarski, Jerzy; Zegrocka-Stendel, Oliwia; Golebiewski, Piotr
European Journal of Organic Chemistry, 2007 , # 4 p. 689 - 703
1240483-20-8
→
反应条件
41639-83-2
拉坦前列腺素(游离酸)
反应条件
1.1: 1H-imidazole / dichloromethane / 18 h / 20 °C 2.1: diisobutylaluminium hydride / dichloromethane; hexane / 0.5 h / -30 °C / Inert atmosphere 2.2: -30 °C 3.1: potassium tert-butylate / tetrahydrofuran / 0.5 h / 20 °C / Inert atmosphere 3.2: 3.25 h / 0 - 20 °C 4.1: hydrogenchloride / water; tetrahydrofuran / 18 h / 20 °C 4.2: pH 6.8 / Aqueous phosphate buffer View Scheme
参考文献
Biffi, Giancarlo; D'Alfonso, Alessandro; Feliciani, Lazzaro; Porta, Alessio; Vidari, Giovanni; Viscardi, Enrico; Zanoni, Giuseppe
Patent: US2012/16136 A1, 2012 ;
1240483-21-9
→
反应条件
41639-83-2
拉坦前列腺素(游离酸)
反应条件
1.1: diisobutylaluminium hydride / dichloromethane; hexane / 0.5 h / -30 °C / Inert atmosphere 1.2: -30 °C 2.1: potassium tert-butylate / tetrahydrofuran / 0.5 h / 20 °C / Inert atmosphere 2.2: 3.25 h / 0 - 20 °C 3.1: hydrogenchloride / water; tetrahydrofuran / 18 h / 20 °C 3.2: pH 6.8 / Aqueous phosphate buffer View Scheme
参考文献
Biffi, Giancarlo; D'Alfonso, Alessandro; Feliciani, Lazzaro; Porta, Alessio; Vidari, Giovanni; Viscardi, Enrico; Zanoni, Giuseppe
Patent: US2012/16136 A1, 2012 ;
1240483-22-0
→
反应条件
41639-83-2
拉坦前列腺素(游离酸)
反应条件
1.1: potassium tert-butylate / tetrahydrofuran / 0.5 h / 20 °C / Inert atmosphere 1.2: 3.25 h / 0 - 20 °C 2.1: hydrogenchloride / water; tetrahydrofuran / 18 h / 20 °C 2.2: pH 6.8 / Aqueous phosphate buffer View Scheme
参考文献
Biffi, Giancarlo; D'Alfonso, Alessandro; Feliciani, Lazzaro; Porta, Alessio; Vidari, Giovanni; Viscardi, Enrico; Zanoni, Giuseppe
Patent: US2012/16136 A1, 2012 ;
17814-85-6
4-羧丁基三苯基溴化膦
→
反应条件
41639-83-2
拉坦前列腺素(游离酸)
反应条件
potassium tert-butylate 1.) THF, RT, 30 min, 2.) THF, -15 to -10 deg C, 4 h; Multistep reaction;
参考文献
Resul, Bahram; Stjernschantz, Johan; No, Kiyo; Liljebris, Charlotta; Selen, Goeran; et al.
Journal of Medicinal Chemistry, 1993 , vol. 36, # 2 p. 243 - 248
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