1.1: thionyl chloride / 3.17 h / 0 - 80 °C 2.1: pyridine / dichloromethane / 0.25 h / 0 - 5 °C 2.2: 0.25 h / 0 - 5 °C 2.3: 4 h / 0 - 20 °C 3.1: 1,8-diazabicyclo[5.4.0]undec-7-ene / nitromethane / 4 h / -25 - -20 °C 4.1: potassium hydroxide; water 4.2: Raney nickel / 20 °C / 2585.81 Torr 4.3: 0 - 3 °C / pH 7 5.1: (S)-α-hydroxybenzeneacetic acid / isopropyl alcohol; water / Resolution of racemate View Scheme

[Rh(acac)2(CO)2]; N-(3-diphenylphosphanylbenzoyl)guanidine; hydrogen in dichloromethane T=40°C; P=11251.1 Torr; 29 h; Autoclave; chemoselective reaction;

hydrogenchloride T=25°C; 24 h;

1.1: thionyl chloride / 3.17 h / 0 - 80 °C 2.1: pyridine / dichloromethane / 0.25 h / 0 - 5 °C 2.2: 0.25 h / 0 - 5 °C 2.3: 4 h / 0 - 20 °C 3.1: 1,8-diazabicyclo[5.4.0]undec-7-ene / nitromethane / 4 h / -25 - -20 °C 4.1: potassium hydroxide; water 4.2: Raney nickel / 20 °C / 2585.81 Torr 4.3: 0 - 3 °C / pH 7 View Scheme

1.1: thionyl chloride / 3.17 h / 0 - 80 °C 2.1: pyridine / dichloromethane / 0.25 h / 0 - 5 °C 2.2: 0.25 h / 0 - 5 °C 2.3: 4 h / 0 - 20 °C 3.1: 1,8-diazabicyclo[5.4.0]undec-7-ene / nitromethane / 4 h / -25 - -20 °C 4.1: potassium hydroxide; water 4.2: Raney nickel / 20 °C / 2585.81 Torr 4.3: 0 - 3 °C / pH 7 View Scheme

hydrogen; [rhodium(I)(carbonyl)2(acetylacetonate)] in dichloromethane T=25°C; P=9750.98 Torr; 24 h;

1.1: thionyl chloride / 3.17 h / 0 - 80 °C 2.1: pyridine / dichloromethane / 0.25 h / 0 - 5 °C 2.2: 0.25 h / 0 - 5 °C 2.3: 4 h / 0 - 20 °C 3.1: 1,8-diazabicyclo[5.4.0]undec-7-ene / nitromethane / 4 h / -25 - -20 °C 4.1: potassium hydroxide; water 4.2: Raney nickel / 20 °C / 2585.81 Torr 4.3: 0 - 3 °C / pH 7 View Scheme