1-((吡啶-3-基)甲基)-4-哌啶酮合成路线 （共 8 条）
反应条件
hydrogenchloride in tetrahydrofuran T=20°C; 20 h;
参考文献
Baraldi, Pier Giovanni; Romagnoli, Romeo; Pavani, Maria Giovanna; Del Carmen Nunez, Maria; Tabrizi, Mojgan Aghazadeh; Shryock, John C.; Leung, Edward; Moorman, Allan R.; Uluoglu, Canan; Iannotta, Valeria; Merighi, Stefania; Borea, Pier Andrea
Journal of Medicinal Chemistry, 2003 , vol. 46, # 5 p. 794 - 809
反应条件
sodium carbonate in acetonitrile T=20 - 70°C;
参考文献
Faul, Margaret M.; Kobierski, Michael E.; Kopach, Michael E.
Journal of Organic Chemistry, 2003 , vol. 68, # 14 p. 5739 - 5741
反应条件
1: With hydrogenchloride; water Reflux; 2: With sodium hydroxide in water T=20°C;
参考文献
Sun, Chuan-Wen; Wang, Hai-Feng; Zhu, Jun; Yang, Ding-Rong; Xing, Jiahua; Jin, Jia
Journal of Heterocyclic Chemistry, 2013 , vol. 50, # 6 p. 1374 - 1380
反应条件
1: 82 percent / triethylamine / CH2Cl2 2: 54 percent / LiAlH4 / tetrahydrofuran / 4 h / 20 °C 3: 57 percent / aq. HCl / tetrahydrofuran / 20 h / 20 °C View Scheme
参考文献
Baraldi, Pier Giovanni; Romagnoli, Romeo; Pavani, Maria Giovanna; Del Carmen Nunez, Maria; Tabrizi, Mojgan Aghazadeh; Shryock, John C.; Leung, Edward; Moorman, Allan R.; Uluoglu, Canan; Iannotta, Valeria; Merighi, Stefania; Borea, Pier Andrea
Journal of Medicinal Chemistry, 2003 , vol. 46, # 5 p. 794 - 809
反应条件
1: 82 percent / triethylamine / CH2Cl2 2: 54 percent / LiAlH4 / tetrahydrofuran / 4 h / 20 °C 3: 57 percent / aq. HCl / tetrahydrofuran / 20 h / 20 °C View Scheme
参考文献
Baraldi, Pier Giovanni; Romagnoli, Romeo; Pavani, Maria Giovanna; Del Carmen Nunez, Maria; Tabrizi, Mojgan Aghazadeh; Shryock, John C.; Leung, Edward; Moorman, Allan R.; Uluoglu, Canan; Iannotta, Valeria; Merighi, Stefania; Borea, Pier Andrea
Journal of Medicinal Chemistry, 2003 , vol. 46, # 5 p. 794 - 809
反应条件
1: 54 percent / LiAlH4 / tetrahydrofuran / 4 h / 20 °C 2: 57 percent / aq. HCl / tetrahydrofuran / 20 h / 20 °C View Scheme
参考文献
Baraldi, Pier Giovanni; Romagnoli, Romeo; Pavani, Maria Giovanna; Del Carmen Nunez, Maria; Tabrizi, Mojgan Aghazadeh; Shryock, John C.; Leung, Edward; Moorman, Allan R.; Uluoglu, Canan; Iannotta, Valeria; Merighi, Stefania; Borea, Pier Andrea
Journal of Medicinal Chemistry, 2003 , vol. 46, # 5 p. 794 - 809
反应条件
1.1: sodium methylate / methanol; toluene / |Reflux 2.1: hydrogenchloride; water / |Reflux 2.2: 20 °C View Scheme
参考文献
Sun, Chuan-Wen; Wang, Hai-Feng; Zhu, Jun; Yang, Ding-Rong; Xing, Jiahua; Jin, Jia
Journal of Heterocyclic Chemistry, 2013 , vol. 50, # 6 p. 1374 - 1380
反应条件
1.1: methanol / |Reflux 2.1: sodium methylate / methanol; toluene / |Reflux 3.1: hydrogenchloride; water / |Reflux 3.2: 20 °C View Scheme
参考文献
Sun, Chuan-Wen; Wang, Hai-Feng; Zhu, Jun; Yang, Ding-Rong; Xing, Jiahua; Jin, Jia
Journal of Heterocyclic Chemistry, 2013 , vol. 50, # 6 p. 1374 - 1380
