2,2,3-三甲基-3-丁烯酸合成路线 （共 22 条）
参考文献
Courtot
Bulletin de la Societe Chimique de France, 1906 , vol. <3>35, p. 302
参考文献
Blaise; Courtot
Bulletin de la Societe Chimique de France, 1906 , vol. <3> 35, p. 591,597
Comptes Rendus Hebdomadaires des Seances de l'Academie des Sciences, 1905 , vol. 141, p. 725
反应条件
potassium hydroxide in ethanol
2 h; Heating;
参考文献
Fraenkel, Gideon; Duncan, Joseph H.; Wang, Jinhai
Journal of the American Chemical Society, 1999 , vol. 121, # 2 p. 432 - 443
反应条件
1: 2,3-dimethyl-buta-1,3-diene With ethyl magnesium chloride; [NiCl2Py4] in tetrahydrofuran
T=20°C; Addition; Hydromagnesation; 40 h;
2: carbon dioxide in tetrahydrofuran
Carboxylation;
参考文献
Viktorov; Zubritskii
Russian Journal of Organic Chemistry, 1999 , vol. 35, # 12 p. 1755 - 1765
反应条件
potassium hydroxide in methanol; water
17 h; Heating;
参考文献
Karpf, Martin
Helvetica Chimica Acta, 1984 , vol. 67, # 1 p. 73 - 85
反应条件
1: 86 percent / POCl3, pyridine / 5 h / Ambient temperature
2: 81 percent / aq. KOH / ethanol / 2 h / Heating
View Scheme
参考文献
Fraenkel, Gideon; Duncan, Joseph H.; Wang, Jinhai
Journal of the American Chemical Society, 1999 , vol. 121, # 2 p. 432 - 443
反应条件
1: 2,3-dimethyl-buta-1,3-diene With isopropylmagnesium chloride; [NiCl2Py4] in tetrahydrofuran
T=20°C; Addition; Hydromagnesation; Dimerization; 40 h;
2: carbon dioxide in tetrahydrofuran
Carboxylation;
参考文献
Viktorov; Zubritskii
Russian Journal of Organic Chemistry, 1999 , vol. 35, # 12 p. 1755 - 1765
反应条件
1.1: 40 percent / HBr / H2O
2.1: EtMgCl / NiPy4Cl2 / tetrahydrofuran / 40 h / 20 °C
2.2: 36 percent / tetrahydrofuran
View Scheme
参考文献
Viktorov; Zubritskii
Russian Journal of Organic Chemistry, 1999 , vol. 35, # 12 p. 1755 - 1765
反应条件
potassium hydroxide in ethylene glycol
T=140°C; 65 h;
参考文献
Fleury,J.-P.; Bader,A.
Bulletin de la Societe Chimique de France, 1965 , p. 951 - 957
反应条件
1: 83 percent / tetrahydrofuran / 2 h / 25 °C
2: 92 percent / KOH / methanol; H2O / 17 h / Heating
View Scheme
参考文献
Karpf, Martin
Helvetica Chimica Acta, 1984 , vol. 67, # 1 p. 73 - 85
