N-Boc-4-氟-4-哌啶甲酸乙酯合成路线 (共 5 条)
反应条件
1: With lithium diisopropyl amide in tetrahydrofuran; n-heptane; ethylbenzene T=0°C; 1.5 h; 2: With N-fluoro-N-(phenylsulfonyl)benzene-sulfonamide in tetrahydrofuran; n-heptane; ethylbenzene T=0 - 20°C; 18.5 h;
参考文献
US2007/66644 A1, ;
Page/Page column 9 ;
US 20070066644 A1
反应条件
hydrogenchloride in 1,4-dioxane T=20°C; 0.5 h; Cooling with ice;
参考文献
BIOTA EUROPE LTD.
Patent: US2012/88750 A1, 2012 ;
Location in patent: Page/Page column 34; 35 ;
反应条件
1: With lithium aluminium tetrahydride in tetrahydrofuran T=0°C; 0.166667 h; 2: With sodium hydroxide; water in tetrahydrofuran; diethyl ether T=20°C;
参考文献
CANCER RESEARCH TECHNOLOGY LIMITED
Patent: WO2009/44162 A1, 2009 ;
Location in patent: Page/Page column 247 ;
WO 2009/044162 A1
参考文献
MERCK and CO., INC.
Patent: WO2007/2884 A2, 2007 ;
Location in patent: Page/Page column 24-25 ;
WO 2007/002884 A2
反应条件
lithium hydroxide; water in tetrahydrofuran; methanol
T=45°C; 6 h;
参考文献
SCHERING CORPORATION
Patent: WO2008/108958 A2, 2008 ;
Location in patent: Page/Page column 54 ;