1: 218 mg / aq. NaOH / dioxane; methanol / 2 h / 20 °C 2: 96 percent / H2 / Pd/C / methanol; dioxane / 20 °C 3: 85 percent / K2CO3 / acetone / 0.5 h / Heating 4: 91 percent / K2CO3 / acetone / 0.33 h / Heating 5: TsOH*H2O; AcOH / toluene / 0.75 h / 110 °C 6: 95 percent / BCl3 / CH2Cl2 / 0.25 h / 15 °C 7: 66 percent / aq. NaOH / methanol; dioxane / 1 h / 20 °C View Scheme

1: 71 percent / CuI; Et3N; PPh3 / PdCl2 / dimethylformamide / 2 h / 75 °C 2: 96 percent / H2 / Pd/C / methanol; dioxane 3: 84 percent / K2CO3 / acetone / 0.5 h / Heating 4: 91 percent / K2CO3 / acetone / 0.33 h / 60 °C 5: BF3*OEt2 6: aq. NaOH / methanol; dioxane / 20 °C View Scheme

1: 96 percent / H2 / Pd/C / methanol; dioxane 2: 84 percent / K2CO3 / acetone / 0.5 h / Heating 3: 91 percent / K2CO3 / acetone / 0.33 h / 60 °C 4: BF3*OEt2 5: aq. NaOH / methanol; dioxane / 20 °C View Scheme

1: 85 percent / K2CO3 / acetone / 0.5 h / Heating 2: 91 percent / K2CO3 / acetone / 0.33 h / Heating 3: TsOH*H2O; AcOH / toluene / 0.75 h / 110 °C 4: 95 percent / BCl3 / CH2Cl2 / 0.25 h / 15 °C 5: 66 percent / aq. NaOH / methanol; dioxane / 1 h / 20 °C View Scheme

1: 91 percent / K2CO3 / acetone / 0.33 h / Heating 2: TsOH*H2O; AcOH / toluene / 0.75 h / 110 °C 3: 95 percent / BCl3 / CH2Cl2 / 0.25 h / 15 °C 4: 66 percent / aq. NaOH / methanol; dioxane / 1 h / 20 °C View Scheme

1: TsOH*H2O; AcOH / toluene / 0.75 h / 110 °C 2: 95 percent / BCl3 / CH2Cl2 / 0.25 h / 15 °C 3: 66 percent / aq. NaOH / methanol; dioxane / 1 h / 20 °C View Scheme

1: 95 percent / BCl3 / CH2Cl2 / 0.25 h / 15 °C 2: 66 percent / aq. NaOH / methanol; dioxane / 1 h / 20 °C View Scheme