(9E,26E)-2,15,17,29-四羟基-11-甲氧基-3,7,12,14,16,18,22-七甲基-26-{[(4-辛烷基氧基)氨基]亚甲基}-6,23,27-三氧代-8,30-二氧杂-24-氮杂四环[23.3.1.14,7.05,28]三十碳-1(28),2,4,9,19,21,25(29)-庚烯-13-基乙酸酯合成路线 （共 2 条）
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41776-72-1(9E,26E)-2,15,17,29-四羟基-11-甲氧基-3,7,12,14,16,18,22-七甲基-26-{[(4-辛烷基氧基)氨基]亚甲基}-6,23,27-三氧代-8,30-二氧杂-24-氮杂四环[23.3.1.14,7.05,28]三十碳-1(28),2,4,9,19,21,25(29)-庚烯-13-基乙酸酯
反应条件
1: (i) HONHCO2Et, KOH, EtOH, (ii) NaOH
2: tetrahydrofuran
View Scheme
参考文献
Cricchio; Lancini; Tamborini; Sensi
Journal of Medicinal Chemistry, 1974 , vol. 17, # 4 p. 396 - 403
→
41776-72-1(9E,26E)-2,15,17,29-四羟基-11-甲氧基-3,7,12,14,16,18,22-七甲基-26-{[(4-辛烷基氧基)氨基]亚甲基}-6,23,27-三氧代-8,30-二氧杂-24-氮杂四环[23.3.1.14,7.05,28]三十碳-1(28),2,4,9,19,21,25(29)-庚烯-13-基乙酸酯
参考文献
Cricchio; Lancini; Tamborini; Sensi
Journal of Medicinal Chemistry, 1974 , vol. 17, # 4 p. 396 - 403
